Search Results
Overview
| Uniprot ID | O43187 |
|---|---|
| Protein Name | Interleukin-1 receptor-associated kinase-like 2 |
| Gene Name | IRAK2 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 363 | AHLCPVNKRSKYTMM |
| 443 | TASLCSRKTGVENVM |
| 94 | AQIILNWKPAPEIRC |
Function
Binds to the IL-1 type I receptor following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization
Protein Sequence
10
MACYIYQLPS
20
WVLDDLCRNM
30
DALSEWDWME
40
FASYVITDLT
50
QLRKIKSMER
60
VQGVSITREL
70
LWWWGMRQAT
80
VQQLVDLLCR
90
LELYRAAQII
100
LNWKPAPEIR
110
CPIPAFPDSV
120
KPEKPLAASV
130
RKAEDEQEEG
140
QPVRMATFPG
150
PGSSPARAHQ
160
PAFLQPPEED
170
APHSLRSDLP
180
TSSDSKDFST
190
SIPKQEKLLS
200
LAGDSLFWSE
210
ADVVQATDDF
220
NQNRKISQGT
230
FADVYRGHRH
240
GKPFVFKKLR
250
ETACSSPGSI
260
ERFFQAELQI
270
CLRCCHPNVL
280
PVLGFCAARQ
290
FHSFIYPYMA
300
NGSLQDRLQG
310
QGGSDPLPWP
320
QRVSICSGLL
330
CAVEYLHGLE
340
IIHSNVKSSN
350
VLLDQNLTPK
360
LAHPMAHLCP
370
VNKRSKYTMM
380
KTHLLRTSAA
390
YLPEDFIRVG
400
QLTKRVDIFS
410
CGIVLAEVLT
420
GIPAMDNNRS
430
PVYLKDLLLS
440
DIPSSTASLC
450
SRKTGVENVM
460
AKEICQKYLE
470
KGAGRLPEDC
480
AEALATAACL
490
CLRRRNTSLQ
500
EVCGSVAAVE
510
ERLRGRETLL
520
PWSGLSEGTG
530
SSSNTPEETD
540
DVDNSSLDAS
550
SSMSVAPWAG
560
AATPLLPTEN
570
GEGRLRVIVG
580
READSSSEAC
590
VGLEPPQDVT
600
ETSWQIEINE
610
AKRKLMENIL
620
LYKEEKVDSI
ELFGP
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0010008 | endosome membrane |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0005886 | plasma membrane |
| Molecular Function | GO:0005524 | ATP binding |
| Molecular Function | GO:0060090 | molecular adaptor activity |
| Molecular Function | GO:0046982 | protein heterodimerization activity |
| Molecular Function | GO:0042803 | protein homodimerization activity |
| Molecular Function | GO:0004672 | protein kinase activity |
| Molecular Function | GO:0035591 | signaling adaptor activity |
| Biological Process | GO:0007249 | canonical NF-kappaB signal transduction |
| Biological Process | GO:0006954 | inflammatory response |
| Biological Process | GO:0070498 | interleukin-1-mediated signaling pathway |
| Biological Process | GO:0035556 | intracellular signal transduction |
| Biological Process | GO:0031663 | lipopolysaccharide-mediated signaling pathway |
| Biological Process | GO:0002755 | MyD88-dependent toll-like receptor signaling pathway |
| Biological Process | GO:0043124 | negative regulation of canonical NF-kappaB signal transduction |
| Biological Process | GO:0044546 | NLRP3 inflammasome complex assembly |
| Biological Process | GO:0043123 | positive regulation of canonical NF-kappaB signal transduction |
| Biological Process | GO:0006468 | protein phosphorylation |
| Biological Process | GO:0001959 | regulation of cytokine-mediated signaling pathway |
| Biological Process | GO:0043405 | regulation of MAP kinase activity |
| Biological Process | GO:0070555 | response to interleukin-1 |
| Biological Process | GO:0008063 | Toll signaling pathway |
| Biological Process | GO:0034142 | toll-like receptor 4 signaling pathway |
| Biological Process | GO:0002224 | toll-like receptor signaling pathway |
Reference
[1] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.