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Overview

Uniprot IDO43237
Protein NameCytoplasmic dynein 1 light intermediate chain 2
Gene NameDYNC1LI2
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
352 VRKLVHDKELAAEDE
372 KQQSLLAKQPATPTR
440 FNSLLSKKTGSPGSP
457 GGVQSTAKKSGQKTV
458 GVQSTAKKSGQKTVL
462 TAKKSGQKTVLSNVQ

Function

Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes

Protein Sequence

10 MAPVGVEKKL 20 LLGPNGPAVA 30 AAGDLTSEEE 40 EGQSLWSSIL 50 SEVSTRARSK 60 LPSGKNILVF 70 GEDGSGKTTL 80 MTKLQGAEHG 90 KKGRGLEYLY 100 LSVHDEDRDD 110 HTRCNVWILD 120 GDLYHKGLLK 130 FAVSAESLPE 140 TLVIFVADMS 150 RPWTVMESLQ 160 KWASVLREHI 170 DKMKIPPEKM 180 RELERKFVKD 190 FQDYMEPEEG 200 CQGSPQRRGP 210 LTSGSDEENV 220 ALPLGDNVLT 230 HNLGIPVLVV 240 CTKCDAVSVL 250 EKEHDYRDEH 260 LDFIQSHLRR 270 FCLQYGAALI 280 YTSVKEEKNL 290 DLLYKYIVHK 300 TYGFHFTTPA 310 LVVEKDAVFI 320 PAGWDNEKKI 330 AILHENFTTV 340 KPEDAYEDFI 350 VKPPVRKLVH 360 DKELAAEDEQ 370 VFLMKQQSLL 380 AKQPATPTRA 390 SESPARGPSG 400 SPRTQGRGGP 410 ASVPSSSPGT 420 SVKKPDPNIK 430 NNAASEGVLA 440 SFFNSLLSKK 450 TGSPGSPGAG 460 GVQSTAKKSG 470 QKTVLSNVQE 480 ELDRMTRKPD 490 SMVTNSSTEN EA

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005813 centrosome
Cellular Component GO:0005868 cytoplasmic dynein complex
Cellular Component GO:0005829 cytosol
Cellular Component GO:0000776 kinetochore
Cellular Component GO:0005770 late endosome
Cellular Component GO:0001673 male germ cell nucleus
Cellular Component GO:0016020 membrane
Cellular Component GO:0005874 microtubule
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0045504 dynein heavy chain binding
Molecular Function GO:0042802 identical protein binding
Biological Process GO:1990090 cellular response to nerve growth factor stimulus
Biological Process GO:0000226 microtubule cytoskeleton organization
Biological Process GO:0007018 microtubule-based movement
Biological Process GO:0032388 positive regulation of intracellular transport

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Lin Y, Chen M, Wang D, Yu Y, Chen R et al.. Multi-Proteomic Analysis Reveals the Effect of Protein Lactylation on Matrix and Cholesterol Metabolism in Tendinopathy.. J Proteome Res 22(6):1712-1722. 2023 Jun 2. PMID: 37159428.

[3] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.

[4] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[5] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.