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Overview

Uniprot IDO43242
Protein Name26S proteasome non-ATPase regulatory subunit 3
Gene NamePSMD3
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
14 ARRRGADKAKPPPGG
2 ******MKQEGSARR
315 TMTNALRKAPQHTAV
503 FPPKSYNKDLESAEE
54 STGEADGKTAAAAAE
89 LEKAVSGKEPRFVLR

Function

Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair

Protein Sequence

10 MKQEGSARRR 20 GADKAKPPPG 30 GGEQEPPPPP 40 APQDVEMKEE 50 AATGGGSTGE 60 ADGKTAAAAA 70 EHSQRELDTV 80 TLEDIKEHVK 90 QLEKAVSGKE 100 PRFVLRALRM 110 LPSTSRRLNH 120 YVLYKAVQGF 130 FTSNNATRDF 140 LLPFLEEPMD 150 TEADLQFRPR 160 TGKAASTPLL 170 PEVEAYLQLL 180 VVIFMMNSKR 190 YKEAQKISDD 200 LMQKISTQNR 210 RALDLVAAKC 220 YYYHARVYEF 230 LDKLDVVRSF 240 LHARLRTATL 250 RHDADGQATL 260 LNLLLRNYLH 270 YSLYDQAEKL 280 VSKSVFPEQA 290 NNNEWARYLY 300 YTGRIKAIQL 310 EYSEARRTMT 320 NALRKAPQHT 330 AVGFKQTVHK 340 LLIVVELLLG 350 EIPDRLQFRQ 360 PSLKRSLMPY 370 FLLTQAVRTG 380 NLAKFNQVLD 390 QFGEKFQADG 400 TYTLIIRLRH 410 NVIKTGVRMI 420 SLSYSRISLA 430 DIAQKLQLDS 440 PEDAEFIVAK 450 AIRDGVIEAS 460 INHEKGYVQS 470 KEMIDIYSTR 480 EPQLAFHQRI 490 SFCLDIHNMS 500 VKAMRFPPKS 510 YNKDLESAEE 520 RREREQQDLE 530 FAKEMAEDDD DSFP

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005829 cytosol
Cellular Component GO:0070062 extracellular exosome
Cellular Component GO:0005576 extracellular region
Cellular Component GO:1904813 ficolin-1-rich granule lumen
Cellular Component GO:0016020 membrane
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Cellular Component GO:0022624 proteasome accessory complex
Cellular Component GO:0000502 proteasome complex
Cellular Component GO:0008541 proteasome regulatory particle, lid subcomplex
Cellular Component GO:0034774 secretory granule lumen
Cellular Component GO:0008021 synaptic vesicle
Molecular Function GO:0030234 enzyme regulator activity
Biological Process GO:0071357 cellular response to type I interferon
Biological Process GO:0010498 proteasomal protein catabolic process
Biological Process GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
Biological Process GO:0061136 regulation of proteasomal protein catabolic process
Biological Process GO:0006979 response to oxidative stress
Biological Process GO:0006511 ubiquitin-dependent protein catabolic process

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[3] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[4] Guo X, Ren X, Yan C, Huang H. Quantitative Proteomics Reveals the Role of Lysine Lactylation in Lenalidomide-Resistance in Multiple Myeloma Cells.. ACS Chem Biol 20(7):1728-1738. 2025 Jul 18. PMID: 40590393.

[5] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.