Search Results
Overview
| Uniprot ID | O43272 |
|---|---|
| Protein Name | Proline dehydrogenase 1, mitochondrial |
| Gene Name | PRODH |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 492 | LKHNAKAKVMVASHN |
| 573 | LENSSLMKGTHRERQ |
Function
Converts proline to delta-1-pyrroline-5-carboxylate
Protein Sequence
10
MALRRALPAL
20
RPCIPRFVPL
30
STAPASREQP
40
AAGPAAVPGG
50
GSATAVRPPV
60
PAVDFGNAQE
70
AYRSRRTWEL
80
ARSLLVLRLC
90
AWPALLARHE
100
QLLYVSRKLL
110
GQRLFNKLMK
120
MTFYGHFVAG
130
EDQESIQPLL
140
RHYRAFGVSA
150
ILDYGVEEDL
160
SPEEAEHKEM
170
ESCTSAAERD
180
GSGTNKRDKQ
190
YQAHWAFGDR
200
RNGVISARTY
210
FYANEAKCDS
220
HMETFLRCIE
230
ASGRVSDDGF
240
IAIKLTALGR
250
PQFLLQFSEV
260
LAKWRCFFHQ
270
MAVEQGQAGL
280
AAMDTKLEVA
290
VLQESVAKLG
300
IASRAEIEDW
310
FTAETLGVSG
320
TMDLLDWSSL
330
IDSRTKLSKH
340
LVVPNAQTGQ
350
LEPLLSRFTE
360
EEELQMTRML
370
QRMDVLAKKA
380
TEMGVRLMVD
390
AEQTYFQPAI
400
SRLTLEMQRK
410
FNVEKPLIFN
420
TYQCYLKDAY
430
DNVTLDVELA
440
RREGWCFGAK
450
LVRGAYLAQE
460
RARAAEIGYE
470
DPINPTYEAT
480
NAMYHRCLDY
490
VLEELKHNAK
500
AKVMVASHNE
510
DTVRFALRRM
520
EELGLHPADH
530
RVYFGQLLGM
540
CDQISFPLGQ
550
AGYPVYKYVP
560
YGPVMEVLPY
570
LSRRALENSS
580
LMKGTHRERQ
590
LLWLELLRRL
600
RTGNLFHRPA
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005743 | mitochondrial inner membrane |
| Cellular Component | GO:0005759 | mitochondrial matrix |
| Cellular Component | GO:0005739 | mitochondrion |
| Molecular Function | GO:0071949 | FAD binding |
| Molecular Function | GO:0016649 | oxidoreductase activity, acting on the CH-NH group of donors, quinone or similar compound as acceptor |
| Molecular Function | GO:0004657 | proline dehydrogenase activity |
| Biological Process | GO:0008631 | intrinsic apoptotic signaling pathway in response to oxidative stress |
| Biological Process | GO:0006562 | L-proline catabolic process |
| Biological Process | GO:0010133 | L-proline catabolic process to L-glutamate |
| Biological Process | GO:0006560 | proline metabolic process |
| Biological Process | GO:1903376 | regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway |
| Biological Process | GO:0019470 | trans-4-hydroxy-L-proline catabolic process |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.