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Overview

Uniprot ID	O43301
Protein Name	Heat shock 70 kDa protein 12A
Gene Name	HSPA12A
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
280	GAGFTQAKEHIRRNR
427	SVEHALRKSNVDFVK
558	PPEKLLVKDGTRWCT
664	AIDIATSKSVKVGID

Function

Adapter protein for SORL1, but not SORT1. Delays SORL1 internalization and affects SORL1 subcellular localization

Protein Sequence

10 MADKEAGGSD 20 GPRETAPTSA 30 YSSPARSLGD 40 TGITPLSPSH 50 IVNDTDSNVS 60 EQQSFLVVVA 70 VDFGTTSSGY 80 AYSFTKEPEC 90 IHVMRRWEGG 100 DPGVSNQKTP 110 TTILLTPERK 120 FHSFGYAARD 130 FYHDLDPNEA 140 KQWLYLEKFK 150 MKLHTTGDLT 160 MDTDLTAANG 170 KKVKALEIFA 180 YALQYFKEQA 190 LKELSDQAGS 200 EFENSDVRWV 210 ITVPAIWKQP 220 AKQFMRQAAY 230 QAGLASPENS 240 EQLIIALEPE 250 AASIYCRKLR 260 LHQMIELSSK 270 AAVNGYSGSD 280 TVGAGFTQAK 290 EHIRRNRQSR 300 TFLVENVIGE 310 IWSELEEGDK 320 YVVVDSGGGT 330 VDLTVHQIRL 340 PEGHLKELYK 350 ATGGPYGSLG 360 VDYEFEKLLY 370 KIFGEDFIEQ 380 FKIKRPAAWV 390 DLMIAFESRK 400 RAAAPDRTNP 410 LNITLPFSFI 420 DYYKKFRGHS 430 VEHALRKSNV 440 DFVKWSSQGM 450 LRMSPDAMNA 460 LFKPTIDSII 470 EHLRDLFQKP 480 EVSTVKFLFL 490 VGGFAEAPLL 500 QQAVQAAFGD 510 QCRIIIPQDV 520 GLTILKGAVL 530 FGLDPAVIKV 540 RRSPLTYGVG 550 VLNRYVEGKH 560 PPEKLLVKDG 570 TRWCTDVFDK 580 FISADQSVAL 590 GELVKRSYTP 600 AKPSQLVIVI 610 NIYSSEHDNV 620 SFITDPGVKK 630 CGTLRLDLTG 640 TSGTAVPARR 650 EIQTLMQFGD 660 TEIKATAIDI 670 ATSKSVKVGI DFLNY

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005737	cytoplasm
Cellular Component	GO:0070062	extracellular exosome
Cellular Component	GO:0005634	nucleus
Molecular Function	GO:0005524	ATP binding

Reference

[1] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.