Search Results
Overview
| Uniprot ID | O43312 |
|---|---|
| Protein Name | Protein MTSS 1 |
| Gene Name | MTSS1 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 270 | PSTTMSRKSSVCSSL |
Function
May be related to cancer progression or tumor metastasis in a variety of organ sites, most likely through an interaction with the actin cytoskeleton
Protein Sequence
10
MEAVIEKECS
20
ALGGLFQTII
30
SDMKGSYPVW
40
EDFINKAGKL
50
QSQLRTTVVA
60
AAAFLDAFQK
70
VADMATNTRG
80
GTREIGSALT
90
RMCMRHRSIE
100
AKLRQFSSAL
110
IDCLINPLQE
120
QMEEWKKVAN
130
QLDKDHAKEY
140
KKARQEIKKK
150
SSDTLKLQKK
160
AKKGRGDIQP
170
QLDSALQDVN
180
DKYLLLEETE
190
KQAVRKALIE
200
ERGRFCTFIS
210
MLRPVIEEEI
220
SMLGEITHLQ
230
TISEDLKSLT
240
MDPHKLPSSS
250
EQVILDLKGS
260
DYSWSYQTPP
270
SSPSTTMSRK
280
SSVCSSLNSV
290
NSSDSRSSGS
300
HSHSPSSHYR
310
YRSSNLAQQA
320
PVRLSSVSSH
330
DSGFISQDAF
340
QSKSPSPMPP
350
EAPNQLSNGF
360
SHYSLSSESH
370
VGPTGAGLFP
380
HCLPASRLLP
390
RVTSVHLPDY
400
AHYYTIGPGM
410
FPSSQIPSWK
420
DWAKPGPYDQ
430
PLVNTLQRRK
440
EKREPDPNGG
450
GPTTASGPPA
460
AAEEAQRPRS
470
MTVSAATRPG
480
EEMEACEELA
490
LALSRGLQLD
500
TQRSSRDSLQ
510
CSSGYSTQTT
520
TPCCSEDTIP
530
SQVSDYDYFS
540
VSGDQEADQQ
550
EFDKSSTIPR
560
NSDISQSYRR
570
MFQAKRPAST
580
AGLPTTLGPA
590
MVTPGVATIR
600
RTPSTKPSVR
610
RGTIGAGPIP
620
IKTPVIPVKT
630
PTVPDLPGVL
640
PAPPDGPEER
650
GEHSPESPSV
660
GEGPQGVTSM
670
PSSMWSGQAS
680
VNPPLPGPKP
690
SIPEEHRQAI
700
PESEAEDQER
710
EPPSATVSPG
720
QIPESDPADL
730
SPRDTPQGED
740
MLNAIRRGVK
750
LKKTTTNDRS
APRFS
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0015629 | actin cytoskeleton |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0030139 | endocytic vesicle |
| Cellular Component | GO:0001726 | ruffle |
| Molecular Function | GO:0003779 | actin binding |
| Molecular Function | GO:0003785 | actin monomer binding |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0005543 | phospholipid binding |
| Molecular Function | GO:0005102 | signaling receptor binding |
| Biological Process | GO:0030036 | actin cytoskeleton organization |
| Biological Process | GO:0034334 | adherens junction maintenance |
| Biological Process | GO:0007155 | cell adhesion |
| Biological Process | GO:0007169 | cell surface receptor protein tyrosine kinase signaling pathway |
| Biological Process | GO:0071498 | cellular response to fluid shear stress |
| Biological Process | GO:2001013 | epithelial cell proliferation involved in renal tubule morphogenesis |
| Biological Process | GO:0072102 | glomerulus morphogenesis |
| Biological Process | GO:0030035 | microspike assembly |
| Biological Process | GO:0050680 | negative regulation of epithelial cell proliferation |
| Biological Process | GO:0072160 | nephron tubule epithelial cell differentiation |
| Biological Process | GO:0007009 | plasma membrane organization |
| Biological Process | GO:0032233 | positive regulation of actin filament bundle assembly |
| Biological Process | GO:0061333 | renal tubule morphogenesis |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.