Search Results

Overview

Uniprot IDO43314
Protein NameInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2
Gene NamePPIP5K2
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
1160 PSSDVPRKTAEISST
1229 RKKNITSKTETHEHK

Function

Bifunctional inositol kinase that acts in concert with the IP6K kinases IP6K1, IP6K2 and IP6K3 to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4 (PubMed:17690096, PubMed:17702752, PubMed:21222653, PubMed:29590114). PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, exocytosis, insulin signaling and neutrophil activation (PubMed:17690096, PubMed:17702752, PubMed:21222653, PubMed:29590114). Phosphorylates inositol hexakisphosphate (InsP6) at position 1 to produce PP-InsP5 which is in turn phosphorylated by IP6Ks to produce (PP)2-InsP4 (PubMed:17690096, PubMed:17702752). Alternatively, phosphorylates PP-InsP5 at position 1, produced by IP6Ks from InsP6, to produce (PP)2-InsP4 (PubMed:17690096, PubMed:17702752). Required for normal hearing (PubMed:29590114)

Protein Sequence

10 MSEAPRFFVG 20 PEDTEINPGN 30 YRHFFHHADE 40 DDEEEDDSPP 50 ERQIVVGICS 60 MAKKSKSKPM 70 KEILERISLF 80 KYITVVVFEE 90 EVILNEPVEN 100 WPLCDCLISF 110 HSKGFPLDKA 120 VAYAKLRNPF 130 VINDLNMQYL 140 IQDRREVYSI 150 LQAEGILLPR 160 YAILNRDPNN 170 PKECNLIEGE 180 DHVEVNGEVF 190 QKPFVEKPVS 200 AEDHNVYIYY 210 PTSAGGGSQR 220 LFRKIGSRSS 230 VYSPESNVRK 240 TGSYIYEEFM 250 PTDGTDVKVY 260 TVGPDYAHAE 270 ARKSPALDGK 280 VERDSEGKEV 290 RYPVILNARE 300 KLIAWKVCLA 310 FKQTVCGFDL 320 LRANGQSYVC 330 DVNGFSFVKN 340 SMKYYDDCAK 350 ILGNIVMREL 360 APQFHIPWSI 370 PLEAEDIPIV 380 PTTSGTMMEL 390 RCVIAVIRHG 400 DRTPKQKMKM 410 EVRHQKFFDL 420 FEKCDGYKSG 430 KLKLKKPKQL 440 QEVLDIARQL 450 LMELGQNNDS 460 EIEENKPKLE 470 QLKTVLEMYG 480 HFSGINRKVQ 490 LTYLPHGCPK 500 TSSEEEDSRR 510 EEPSLLLVLK 520 WGGELTPAGR 530 VQAEELGRAF 540 RCMYPGGQGD 550 YAGFPGCGLL 560 RLHSTYRHDL 570 KIYASDEGRV 580 QMTAAAFAKG 590 LLALEGELTP 600 ILVQMVKSAN 610 MNGLLDSDSD 620 SLSSCQQRVK 630 ARLHEILQKD 640 RDFTAEDYEK 650 LTPSGSISLI 660 KSMHLIKNPV 670 KTCDKVYSLI 680 QSLTSQIRHR 690 MEDPKSSDIQ 700 LYHSETLELM 710 LRRWSKLEKD 720 FKTKNGRYDI 730 SKIPDIYDCI 740 KYDVQHNGSL 750 KLENTMELYR 760 LSKALADIVI 770 PQEYGITKAE 780 KLEIAKGYCT 790 PLVRKIRSDL 800 QRTQDDDTVN 810 KLHPVYSRGV 820 LSPERHVRTR 830 LYFTSESHVH 840 SLLSILRYGA 850 LCNESKDEQW 860 KRAMDYLNVV 870 NELNYMTQIV 880 IMLYEDPNKD 890 LSSEERFHVE 900 LHFSPGAKGC 910 EEDKNLPSGY 920 GYRPASRENE 930 GRRPFKIDND 940 DEPHTSKRDE 950 VDRAVILFKP 960 MVSEPIHIHR 970 KSPLPRSRKT 980 ATNDEESPLS 990 VSSPEGTGTW 1000 LHYTSGVGTG 1010 RRRRRSGEQI 1020 TSSPVSPKSL 1030 AFTSSIFGSW 1040 QQVVSENANY 1050 LRTPRTLVEQ 1060 KQNPTVGSHC 1070 AGLFSTSVLG 1080 GSSSAPNLQD 1090 YARTHRKKLT 1100 SSGCIDDATR 1110 GSAVKRFSIS 1120 FARHPTNGFE 1130 LYSMVPSICP 1140 LETLHNALSL 1150 KQVDEFLASI 1160 ASPSSDVPRK 1170 TAEISSTALR 1180 SSPIMRKKVS 1190 LNTYTPAKIL 1200 PTPPATLKST 1210 KASSKPATSG 1220 PSSAVVPNTS 1230 SRKKNITSKT 1240 ETHEHKKNTG KKK

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005829 cytosol
Molecular Function GO:0033857 5-diphosphoinositol pentakisphosphate 1-kinase activity
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0000829 diphosphoinositol pentakisphosphate kinase activity
Molecular Function GO:0052723 inositol hexakisphosphate 1-kinase activity
Molecular Function GO:0000832 inositol hexakisphosphate 5-kinase activity
Molecular Function GO:0000828 inositol hexakisphosphate kinase activity
Molecular Function GO:0000827 inositol-1,3,4,5,6-pentakisphosphate kinase activity
Biological Process GO:0006020 inositol metabolic process
Biological Process GO:0032958 inositol phosphate biosynthetic process
Biological Process GO:0043647 inositol phosphate metabolic process
Biological Process GO:0007605 sensory perception of sound

Reference

[1] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.