Overview
| Uniprot ID | O43315 |
|---|
| Protein Name | Aquaporin-9 |
|---|
| Gene Name | AQP9 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 19 |
FKQRLVLKSSLAKET |
| 8 |
MQPEGAEKGKSFKQR |
Function
Aquaglyceroporins form homotetrameric transmembrane channels, with each monomer independently mediating glycerol and water transport across the plasma membrane along their osmotic gradient (PubMed:10564231, PubMed:30420639, PubMed:35054513, PubMed:9514918). AQP9 is the primary route for glycerol uptake in hepatocytes, supporting hepatic gluconeogenesis (By similarity). It exhibits broad specificity and may transport various small, non-charged solutes, including carbamides, polyols, purines, and pyrimidines (PubMed:10564231). AQP9 may also facilitate hepatic urea extrusion (PubMed:10564231, PubMed:9514918). Due to its permeability to lactate, AQP9 might participate in the astrocyte-to-neuron lactate shuttle, supplying neurons with energy (PubMed:10564231, PubMed:35054513). Additionally, AQP9 is permeable to arsenite, contributing to arsenic excretion by the liver and providing partial protection against arsenic toxicity (PubMed:10564231). It is also permeable to H2O2 in vivo (PubMed:26837049). Could also be permeable to ammonium (By similarity)
Protein Sequence
10
MQPEGAEKGK
20
SFKQRLVLKS
30
SLAKETLSEF
40
LGTFILIVLG
50
CGCVAQAILS
60
RGRFGGVITI
70
NVGFSMAVAM
80
AIYVAGGVSG
90
GHINPAVSLA
100
MCLFGRMKWF
110
KLPFYVGAQF
120
LGAFVGAATV
130
FGIYYDGLMS
140
FAGGKLLIVG
150
ENATAHIFAT
160
YPAPYLSLAN
170
AFADQVVATM
180
ILLIIVFAIF
190
DSRNLGAPRG
200
LEPIAIGLLI
210
IVIASSLGLN
220
SGCAMNPARD
230
LSPRLFTALA
240
GWGFEVFRAG
250
NNFWWIPVVG
260
PLVGAVIGGL
270
IYVLVIEIHH
280
PEPDSVFKTE
290
QSEDKPEKYE
LSVIM
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0016323 |
basolateral plasma membrane |
| Cellular Component |
GO:0043231 |
intracellular membrane-bounded organelle |
| Cellular Component |
GO:0005886 |
plasma membrane |
| Molecular Function |
GO:0015267 |
channel activity |
| Molecular Function |
GO:0015254 |
glycerol channel activity |
| Molecular Function |
GO:0140070 |
hydrogen peroxide channel activity |
| Molecular Function |
GO:0005345 |
purine nucleobase transmembrane transporter activity |
| Molecular Function |
GO:0005350 |
pyrimidine nucleobase transmembrane transporter activity |
| Molecular Function |
GO:0015265 |
urea channel activity |
| Molecular Function |
GO:0015204 |
urea transmembrane transporter activity |
| Molecular Function |
GO:0015250 |
water channel activity |
| Biological Process |
GO:0015837 |
amine transport |
| Biological Process |
GO:0071320 |
cellular response to cAMP |
| Biological Process |
GO:0071722 |
detoxification of arsenic-containing substance |
| Biological Process |
GO:0015793 |
glycerol transmembrane transport |
| Biological Process |
GO:0006863 |
purine nucleobase transport |
| Biological Process |
GO:0015855 |
pyrimidine nucleobase transport |
| Biological Process |
GO:0071918 |
urea transmembrane transport |
| Biological Process |
GO:0006833 |
water transport |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.