Search Results
Overview
| Uniprot ID | O43347 |
|---|---|
| Protein Name | RNA-binding protein Musashi homolog 1 |
| Gene Name | MSI1 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 76 | MDQAGVDKVLAQSRH |
Function
RNA binding protein that regulates the expression of target mRNAs at the translation level. Regulates expression of the NOTCH1 antagonist NUMB. Binds RNA containing the sequence 5'-GUUAGUUAGUUAGUU-3' and other sequences containing the pattern 5'-[GA]U(1-3)AGU-3'. May play a role in the proliferation and maintenance of stem cells in the central nervous system (By similarity)
Protein Sequence
10
METDAPQPGL
20
ASPDSPHDPC
30
KMFIGGLSWQ
40
TTQEGLREYF
50
GQFGEVKECL
60
VMRDPLTKRS
70
RGFGFVTFMD
80
QAGVDKVLAQ
90
SRHELDSKTI
100
DPKVAFPRRA
110
QPKMVTRTKK
120
IFVGGLSVNT
130
TVEDVKQYFE
140
QFGKVDDAML
150
MFDKTTNRHR
160
GFGFVTFESE
170
DIVEKVCEIH
180
FHEINNKMVE
190
CKKAQPKEVM
200
SPTGSARGRS
210
RVMPYGMDAF
220
MLGIGMLGYP
230
GFQATTYASR
240
SYTGLAPGYT
250
YQFPEFRVER
260
TPLPSAPVLP
270
ELTAIPLTAY
280
GPMAAAAAAA
290
AVVRGTGSHP
300
WTMAPPPGST
310
PSRTGGFLGT
320
TSPGPMAELY
330
GAANQDSGVS
340
SYISAASPAP
350
STGFGHSLGG
360
PLIATAFTNG
YH
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0140693 | molecular condensate scaffold activity |
| Molecular Function | GO:0003729 | mRNA binding |
| Molecular Function | GO:0008266 | poly(U) RNA binding |
| Molecular Function | GO:0042803 | protein homodimerization activity |
| Molecular Function | GO:0003723 | RNA binding |
| Biological Process | GO:0007417 | central nervous system development |
| Biological Process | GO:0030855 | epithelial cell differentiation |
| Biological Process | GO:0007399 | nervous system development |
| Biological Process | GO:0006417 | regulation of translation |
| Biological Process | GO:0009725 | response to hormone |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.