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Overview

Uniprot ID	O43361
Protein Name	Zinc finger protein 749
Gene Name	ZNF749
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
466	IHTDAFSKRSDLIQH

Function

May be involved in transcriptional regulation

Protein Sequence

10 MNLTEDCMVF 20 EDVAIYFSQE 30 EWGILNDAQR 40 HLHSNVMLEN 50 FALLSSVGCW 60 HGAKDEEVPS 70 KQCVSVRVLQ 80 VTIPKPALST 90 LKAQPCKMCS 100 SILKDILHLA 110 EHDGTHPEQG 120 LYTCAAEHDL 130 HQKEQIREKL 140 TRSDEWRPSF 150 VNHSAHVGER 160 NFTCTQGGKD 170 FTASSDLLQQ 180 QVLNSGWKLY 190 RDTQDGEAFQ 200 GEQNDFNSSQ 210 GGKDFCHQHG 220 LFEHQKTHNG 230 ERPYEFSECG 240 ELFRYNSNLI 250 KYQQNHAGER 260 PYEGTEYGKT 270 FIRKSNLVQH 280 QKIHSEGFLS 290 KRSDPIEHQE 300 ILSRPTPYEC 310 TQCGKAFLTQ 320 AHLVGHQKTH 330 TGEQPYECNK 340 CGKFFMYNSK 350 LIRHQKVHTG 360 ERRYECSECG 370 KLFMDSFTLG 380 RHQRVHTGER 390 PFECSICGKF 400 FSHRSTLNMH 410 QRVHAGKRLY 420 KCSECGKAFS 430 LKHNVVQHLK 440 IHTGERPYEC 450 TECEKAFVRK 460 SHLVQHQKIH 470 TDAFSKRSDL 480 IQHKRIDIRP 490 RPYTCSECGK 500 AFLTQAHLVG 510 HQKIHTGERP 520 YECTQCAKAF 530 VRKSHLVQHE 540 KIHTDAFSKR 550 SDLIQHKRID 560 LRPRPYVCSE 570 CGKAFLTQAH 580 LDGHQKIQTG 590 ERRYECNECG 600 KFFLDSYKLV 610 IHQRIHTGEK 620 PYKCSKCGKF 630 FRYRCTLSRH 640 QKVHTGERPY 650 ECSECGKFFR 660 DSYKLIIHQR 670 VHTGEKPYEC 680 SNCGKFLRYR 690 STFIKHHKVC 700 TGEKPHECSK 710 CRELFRTKSS 720 LIIHQQSHTG 730 ESPFKLRECG 740 KDFNKCNTGQ 750 RQKTHTGERS 760 YECGESSKVF 770 KYNSSLIKHQ IIHTGKRP

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005634	nucleus
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific
Molecular Function	GO:0000977	RNA polymerase II transcription regulatory region sequence-specific DNA binding
Molecular Function	GO:0008270	zinc ion binding
Biological Process	GO:0006351	DNA-templated transcription
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.