Search Results

Overview

Uniprot IDO43390
Protein NameHeterogeneous nuclear ribonucleoprotein R
Gene NameHNRNPR
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
103 AFLCGVMKTYRQREK
114 QREKQGSKVQESTKG
126 TKGPDEAKIKALLER
128 GPDEAKIKALLERTG
259 SIPKNKTKENILEEF
341 PEVMAKVKVLFVRNL
374 LERVKKLKDYAFVHF
574 GNVGGKRKADGYNQP
584 GYNQPDSKRRQTNNQ

Function

Component of ribonucleosomes, which are complexes of at least 20 other different heterogeneous nuclear ribonucleoproteins (hnRNP). hnRNP play an important role in processing of precursor mRNA in the nucleus

Protein Sequence

10 MANQVNGNAV 20 QLKEEEEPMD 30 TSSVTHTEHY 40 KTLIEAGLPQ 50 KVAERLDEIF 60 QTGLVAYVDL 70 DERAIDALRE 80 FNEEGALSVL 90 QQFKESDLSH 100 VQNKSAFLCG 110 VMKTYRQREK 120 QGSKVQESTK 130 GPDEAKIKAL 140 LERTGYTLDV 150 TTGQRKYGGP 160 PPDSVYSGVQ 170 PGIGTEVFVG 180 KIPRDLYEDE 190 LVPLFEKAGP 200 IWDLRLMMDP 210 LSGQNRGYAF 220 ITFCGKEAAQ 230 EAVKLCDSYE 240 IRPGKHLGVC 250 ISVANNRLFV 260 GSIPKNKTKE 270 NILEEFSKVT 280 EGLVDVILYH 290 QPDDKKKNRG 300 FCFLEYEDHK 310 SAAQARRRLM 320 SGKVKVWGNV 330 VTVEWADPVE 340 EPDPEVMAKV 350 KVLFVRNLAT 360 TVTEEILEKS 370 FSEFGKLERV 380 KKLKDYAFVH 390 FEDRGAAVKA 400 MDEMNGKEIE 410 GEEIEIVLAK 420 PPDKKRKERQ 430 AARQASRSTA 440 YEDYYYHPPP 450 RMPPPIRGRG 460 RGGGRGGYGY 470 PPDYYGYEDY 480 YDDYYGYDYH 490 DYRGGYEDPY 500 YGYDDGYAVR 510 GRGGGRGGRG 520 APPPPRGRGA 530 PPPRGRAGYS 540 QRGAPLGPPR 550 GSRGGRGGPA 560 QQQRGRGSRG 570 SRGNRGGNVG 580 GKRKADGYNQ 590 PDSKRRQTNN 600 QQNWGSQPIA 610 QQPLQQGGDY 620 SGNYGYNNDN 630 QEFYQDTYGQ QWK

Gene Ontology

Classification GO ID Description
Cellular Component GO:0071013 catalytic step 2 spliceosome
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Cellular Component GO:1990904 ribonucleoprotein complex
Cellular Component GO:0005681 spliceosomal complex
Molecular Function GO:0003729 mRNA binding
Molecular Function GO:0003723 RNA binding
Biological Process GO:0006397 mRNA processing
Biological Process GO:0000398 mRNA splicing, via spliceosome

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[3] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[4] Guo X, Ren X, Yan C, Huang H. Quantitative Proteomics Reveals the Role of Lysine Lactylation in Lenalidomide-Resistance in Multiple Myeloma Cells.. ACS Chem Biol 20(7):1728-1738. 2025 Jul 18. PMID: 40590393.

[5] Chao L, Xu Y, Yang Y, Ao X, Liang J. Identification of lactylation-related biomarkers for diagnosis, prognosis, and treatment responsiveness in triple-negative breast cancer.. World J Surg Oncol 24(1):77. 2026 Jan 22. PMID: 41566505.

[6] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.