Search Results

Overview

Uniprot IDO43399
Protein NameTumor protein D54
Gene NameTPD52L2
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
127 VTQSDLYKKTQETLS
128 TQSDLYKKTQETLSQ
165 MRNSATFKSFEDRVG
70 LRQVLAAKERHCGEL

Function

No function data available.

Protein Sequence

10 MDSAGQDINL 20 NSPNKGLLSD 30 SMTDVPVDTG 40 VAARTPAVEG 50 LTEAEEEELR 60 AELTKVEEEI 70 VTLRQVLAAK 80 ERHCGELKRR 90 LGLSTLGELK 100 QNLSRSWHDV 110 QVSSAYVKTS 120 EKLGEWNEKV 130 TQSDLYKKTQ 140 ETLSQAGQKT 150 SAALSTVGSA 160 ISRKLGDMRN 170 SATFKSFEDR 180 VGTIKSKVVG 190 DRENGSDNLP 200 SSAGSGDKPL SDPAPF

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0048471 perinuclear region of cytoplasm
Molecular Function GO:0042803 protein homodimerization activity
Molecular Function GO:0003723 RNA binding
Biological Process GO:0005975 carbohydrate metabolic process
Biological Process GO:0042127 regulation of cell population proliferation

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[3] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[4] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[5] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.