Search Results

Overview

Uniprot ID	O43426
Protein Name	Polyphosphatidylinositol phosphatase SYNJ1
Gene Name	SYNJ1
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
449	GTGALEGKAKLKDGA
577	GIQEFQDKRSKPTDI

Function

Phosphatase that hydrolyzes phosphate groups from the inositol ring of phosphoinositides and inositol phosphates, in a domain-specific manner (PubMed:10224048, PubMed:18093523, PubMed:23804563, PubMed:27435091, PubMed:33349335, PubMed:40969890). The 5-PPase domain catalyzes removal of the 5-phosphate from substrates such as phosphatidylinositol-4,5-bisphosphate (PtdIns(4,5)P2), phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3), inositol-1,4,5-trisphosphate (Ins(1,4,5)P3) and inositol-1,3,4,5-tetrakisphosphate (Ins(1,3,4,5)P4) (PubMed:18093523, PubMed:23804563, PubMed:27435091, PubMed:33349335, PubMed:40969890). The SAC domain hydrolyzes phosphates at the 3- and 4-positions of the inositol ring, targeting phosphatidylinositol-3-phosphate (PI(3)P), phosphatidylinositol-4-phosphate (PI(4)P), and phosphatidylinositol-3,5-bisphosphate (PI(3,5)P2) (PubMed:10224048, PubMed:18093523, PubMed:23804563, PubMed:27435091). Plays a role in the phosphatidylinositol metabolic process during an unconventional endocytic mechanism, the ultrafast endocytosis where it participates in the rapide neck formation of the newly generated synaptic vesicle through its phosphoinositide 5-phosphatase activity (By similarity). Also, participates in the clathrin uncoating of synaptc vesicle formed via budding from synaptic endosomes after ultrafast endocytosis through combined activity of its phosphatase domains (By similarity). Additionally, regulates actin filament rearrangement by hydrolyzing PIP2 bound to actin regulatory proteins (By similarity)

Protein Sequence

10 MAFSKGFRIY 20 HKLDPPPFSL 30 IVETRHKEEC 40 LMFESGAVAV 50 LSSAEKEAIK 60 GTYSKVLDAY 70 GLLGVLRLNL 80 GDTMLHYLVL 90 VTGCMSVGKI 100 QESEVFRVTS 110 TEFISLRIDS 120 SDEDRISEVR 130 KVLNSGNFYF 140 AWSASGISLD 150 LSLNAHRSMQ 160 EQTTDNRFFW 170 NQSLHLHLKH 180 YGVNCDDWLL 190 RLMCGGVEIR 200 TIYAAHKQAK 210 ACLISRLSCE 220 RAGTRFNVRG 230 TNDDGHVANF 240 VETEQVVYLD 250 DSVSSFIQIR 260 GSVPLFWEQP 270 GLQVGSHRVR 280 MSRGFEANAP 290 AFDRHFRTLK 300 NLYGKQIIVN 310 LLGSKEGEHM 320 LSKAFQSHLK 330 ASEHAADIQM 340 VNFDYHQMVK 350 GGKAEKLHSV 360 LKPQVQKFLD 370 YGFFYFNGSE 380 VQRCQSGTVR 390 TNCLDCLDRT 400 NSVQAFLGLE 410 MLAKQLEALG 420 LAEKPQLVTR 430 FQEVFRSMWS 440 VNGDSISKIY 450 AGTGALEGKA 460 KLKDGARSVT 470 RTIQNNFFDS 480 SKQEAIDVLL 490 LGNTLNSDLA 500 DKARALLTTG 510 SLRVSEQTLQ 520 SASSKVLKSM 530 CENFYKYSKP 540 KKIRVCVGTW 550 NVNGGKQFRS 560 IAFKNQTLTD 570 WLLDAPKLAG 580 IQEFQDKRSK 590 PTDIFAIGFE 600 EMVELNAGNI 610 VSASTTNQKL 620 WAVELQKTIS 630 RDNKYVLLAS 640 EQLVGVCLFV 650 FIRPQHAPFI 660 RDVAVDTVKT 670 GMGGATGNKG 680 AVAIRMLFHT 690 TSLCFVCSHF 700 AAGQSQVKER 710 NEDFIEIARK 720 LSFPMGRMLF 730 SHDYVFWCGD 740 FNYRIDLPNE 750 EVKELIRQQN 760 WDSLIAGDQL 770 INQKNAGQVF 780 RGFLEGKVTF 790 APTYKYDLFS 800 DDYDTSEKCR 810 TPAWTDRVLW 820 RRRKWPFDRS 830 AEDLDLLNAS 840 FQDESKILYT 850 WTPGTLLHYG 860 RAELKTSDHR 870 PVVALIDIDI 880 FEVEAEERQN 890 IYKEVIAVQG 900 PPDGTVLVSI 910 KSSLPENNFF 920 DDALIDELLQ 930 QFASFGEVIL 940 IRFVEDKMWV 950 TFLEGSSALN 960 VLSLNGKELL 970 NRTITIALKS 980 PDWIKNLEEE 990 MSLEKISIAL 1000 PSSTSSTLLG 1010 EDAEVAADFD 1020 MEGDVDDYSA 1030 EVEELLPQHL 1040 QPSSSSGLGT 1050 SPSSSPRTSP 1060 CQSPTISEGP 1070 VPSLPIRPSR 1080 APSRTPGPPS 1090 AQSSPIDAQP 1100 ATPLPQKDPA 1110 QPLEPKRPPP 1120 PRPVAPPTRP 1130 APPQRPPPPS 1140 GARSPAPTRK 1150 EFGGIGAPPS 1160 PGVARREMEA 1170 PKSPGTTRKD 1180 NIGRSQPSPQ 1190 AGLAGPGPAG 1200 YSTARPTIPP 1210 RAGVISAPQS 1220 HARASAGRLT 1230 PESQSKTSET 1240 SKGSTFLPEP 1250 LKPQAAFPPQ 1260 SSLPPPAQRL 1270 QEPLVPVAAP 1280 MPQSGPQPNL 1290 ETPPQPPPRS 1300 RSSHSLPSEA 1310 SSQPQVKTNG 1320 ISDGKRESPL 1330 KIDPFEDLSF 1340 NLLAVSKAQL 1350 SVQTSPVPTP 1360 DPKRLIQLPS 1370 ATQSNVLSSV 1380 SCMPTMPPIP 1390 ARSQSQENMR 1400 SSPNPFITGL 1410 TRTNPFSDRT 1420 AAPGNPFRAK 1430 SEESEATSWF 1440 SKEEPVTISP 1450 FPSLQPLGHN 1460 KSRASSSLDG 1470 FKDSFDLQGQ 1480 STLKISNPKG 1490 WVTFEEEEDF 1500 GVKGKSKSAC 1510 SDLLGNQPSS 1520 FSGSNLTLND 1530 DWNKGTNVSF 1540 CVLPSRRPPP 1550 PPVPLLPPGT 1560 SPPVDPFTTL 1570 ASKASPTLDF TER

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0030132	clathrin coat of coated pit
Biological Process	GO:0036465	synaptic vesicle recycling
Biological Process	GO:0048489	synaptic vesicle transport
Biological Process	GO:0016191	synaptic vesicle uncoating
Cellular Component	GO:0005737	cytoplasm
Cellular Component	GO:0005829	cytosol
Cellular Component	GO:0016020	membrane
Cellular Component	GO:0030117	membrane coat
Cellular Component	GO:0048471	perinuclear region of cytoplasm
Cellular Component	GO:0098793	presynapse
Cellular Component	GO:0097060	synaptic membrane
Cellular Component	GO:0043195	terminal bouton
Cellular Component	GO:0012506	vesicle membrane
Molecular Function	GO:0052658	inositol-1,4,5-trisphosphate 5-phosphatase activity
Molecular Function	GO:0034596	phosphatidylinositol phosphate 4-phosphatase activity
Molecular Function	GO:0034595	phosphatidylinositol phosphate 5-phosphatase activity
Molecular Function	GO:0052866	phosphatidylinositol phosphate phosphatase activity
Molecular Function	GO:0034485	phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity
Molecular Function	GO:0052629	phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity
Molecular Function	GO:0043813	phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity
Molecular Function	GO:0004438	phosphatidylinositol-3-phosphate phosphatase activity
Molecular Function	GO:0004439	phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity
Molecular Function	GO:0043812	phosphatidylinositol-4-phosphate phosphatase activity
Molecular Function	GO:0102091	phosphatidylinositol-5-phosphate phosphatase activity
Molecular Function	GO:0003723	RNA binding
Biological Process	GO:1902634	1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate catabolic process
Biological Process	GO:0043647	inositol phosphate metabolic process
Biological Process	GO:0007612	learning
Biological Process	GO:0061024	membrane organization
Biological Process	GO:0006836	neurotransmitter transport
Biological Process	GO:0006661	phosphatidylinositol biosynthetic process
Biological Process	GO:0031161	phosphatidylinositol catabolic process
Biological Process	GO:0046856	phosphatidylinositol dephosphorylation
Biological Process	GO:0046488	phosphatidylinositol metabolic process
Biological Process	GO:1904980	positive regulation of endosome organization
Biological Process	GO:0048488	synaptic vesicle endocytosis
Biological Process	GO:0016082	synaptic vesicle priming

Reference

[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[2] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.