Search Results

Overview

Uniprot ID	O43432
Protein Name	Eukaryotic translation initiation factor 4 gamma 3
Gene Name	EIF4G3
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
1077	AQLGSWGKGSSGGAK
714	GQRREPRKIITVSVK
944	GKDLDFEKAKPRMDQ
946	DLDFEKAKPRMDQYF

Function

Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome (PubMed:9418880). Functional homolog of EIF4G1 (PubMed:9418880)

Protein Sequence

10 MNSQPQTRSP 20 FFQRPQIQPP 30 RATIPNSSPS 40 IRPGAQTPTA 50 VYQANQHIMM 60 VNHLPMPYPV 70 PQGPQYCIPQ 80 YRHSGPPYVG 90 PPQQYPVQPP 100 GPGPFYPGPG 110 PGDFPNAYGT 120 PFYPSQPVYQ 130 SAPIIVPTQQ 140 QPPPAKREKK 150 TIRIRDPNQG 160 GKDITEEIMS 170 GGGSRNPTPP 180 IGRPTSTPTP 190 PQQLPSQVPE 200 HSPVVYGTVE 210 SAHLAASTPV 220 TAASDQKQEE 230 KPKPDPVLKS 240 PSPVLRLVLS 250 GEKKEQEGQT 260 SETTAIVSIA 270 ELPLPPSPTT 280 VSSVARSTIA 290 APTSSALSSQ 300 PIFTTAIDDR 310 CELSSPREDT 320 IPIPSLTSCT 330 ETSDPLPTNE 340 NDDDICKKPC 350 SVAPNDIPLV 360 SSTNLINEIN 370 GVSEKLSATE 380 SIVEIVKQEV 390 LPLTLELEIL 400 ENPPEEMKLE 410 CIPAPITPST 420 VPSFPPTPPT 430 PPASPPHTPV 440 IVPAAATTVS 450 SPSAAITVQR 460 VLEEDESIRT 470 CLSEDAKEIQ 480 NKIEVEADGQ 490 TEEILDSQNL 500 NSRRSPVPAQ 510 IAITVPKTWK 520 KPKDRTRTTE 530 EMLEAELELK 540 AEEELSIDKV 550 LESEQDKMSQ 560 GFHPERDPSD 570 LKKVKAVEEN 580 GEEAEPVRNG 590 AESVSEGEGI 600 DANSGSTDSS 610 GDGVTFPFKP 620 ESWKPTDTEG 630 KKQYDREFLL 640 DFQFMPACIQ 650 KPEGLPPISD 660 VVLDKINQPK 670 LPMRTLDPRI 680 LPRGPDFTPA 690 FADFGRQTPG 700 GRGVPLLNVG 710 SRRSQPGQRR 720 EPRKIITVSV 730 KEDVHLKKAE 740 NAWKPSQKRD 750 SQADDPENIK 760 TQELFRKVRS 770 ILNKLTPQMF 780 NQLMKQVSGL 790 TVDTEERLKG 800 VIDLVFEKAI 810 DEPSFSVAYA 820 NMCRCLVTLK 830 VPMADKPGNT 840 VNFRKLLLNR 850 CQKEFEKDKA 860 DDDVFEKKQK 870 ELEAASAPEE 880 RTRLHDELEE 890 AKDKARRRSI 900 GNIKFIGELF 910 KLKMLTEAIM 920 HDCVVKLLKN 930 HDEESLECLC 940 RLLTTIGKDL 950 DFEKAKPRMD 960 QYFNQMEKIV 970 KERKTSSRIR 980 FMLQDVIDLR 990 LCNWVSRRAD 1000 QGPKTIEQIH 1010 KEAKIEEQEE 1020 QRKVQQLMTK 1030 EKRRPGVQRV 1040 DEGGWNTVQG 1050 AKNSRVLDPS 1060 KFLKITKPTI 1070 DEKIQLVPKA 1080 QLGSWGKGSS 1090 GGAKASETDA 1100 LRSSASSLNR 1110 FSALQPPAPS 1120 GSTPSTPVEF 1130 DSRRTLTSRG 1140 SMGREKNDKP 1150 LPSATARPNT 1160 FMRGGSSKDL 1170 LDNQSQEEQR 1180 REMLETVKQL 1190 TGGVDVERNS 1200 TEAERNKTRE 1210 SAKPEISAMS 1220 AHDKAALSEE 1230 ELERKSKSII 1240 DEFLHINDFK 1250 EAMQCVEELN 1260 AQGLLHVFVR 1270 VGVESTLERS 1280 QITRDHMGQL 1290 LYQLVQSEKL 1300 SKQDFFKGFS 1310 ETLELADDMA 1320 IDIPHIWLYL 1330 AELVTPMLKE 1340 GGISMRELTI 1350 EFSKPLLPVG 1360 RAGVLLSEIL 1370 HLLCKQMSHK 1380 KVGALWREAD 1390 LSWKDFLPEG 1400 EDVHNFLLEQ 1410 KLDFIESDSP 1420 CSSEALSKKE 1430 LSAEELYKRL 1440 EKLIIEDKAN 1450 DEQIFDWVEA 1460 NLDEIQMSSP 1470 TFLRALMTAV 1480 CKAAIIADSS 1490 TFRVDTAVIK 1500 QRVPILLKYL 1510 DSDTEKELQA 1520 LYALQASIVK 1530 LDQPANLLRM 1540 FFDCLYDEEV 1550 ISEDAFYKWE 1560 SSKDPAEQNG 1570 KGVALKSVTA 1580 FFTWLREAEE ESEDN

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005737	cytoplasm
Molecular Function	GO:0008135	translation factor activity, RNA binding
Molecular Function	GO:0003743	translation initiation factor activity
Biological Process	GO:0045727	positive regulation of translation
Biological Process	GO:0006446	regulation of translational initiation
Biological Process	GO:0007286	spermatid development
Biological Process	GO:0006413	translational initiation
Cellular Component	GO:0005829	cytosol
Cellular Component	GO:0016281	eukaryotic translation initiation factor 4F complex
Molecular Function	GO:0003729	mRNA binding
Molecular Function	GO:0003723	RNA binding
Molecular Function	GO:0000339	RNA cap binding

Reference

[1] Chao L, Xu Y, Yang Y, Ao X, Liang J. Identification of lactylation-related biomarkers for diagnosis, prognosis, and treatment responsiveness in triple-negative breast cancer.. World J Surg Oncol 24(1):77. 2026 Jan 22. PMID: 41566505.

[2] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.