Search Results

Overview

Uniprot IDO43451
Protein NameMaltase-glucoamylase
Gene NameMGAM
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
848 IIALDENKEAKGELF

Function

Alpha-(1,4) exo-glucosidase involved in breakdown of dietary starch oligosaccharides in small intestine. Cleaves the non-reducing alpha-(1,4)-linked glucose residue in linear dextrins with retention of anomeric center stereochemistry (PubMed:12547908, PubMed:18036614, PubMed:18356321, PubMed:22058037, PubMed:27480812). Mainly hydrolyzes short length oligomaltoses having two to seven glucose residues (PubMed:12547908, PubMed:18036614, PubMed:18356321, PubMed:22058037, PubMed:27480812). Can cleave alpha-(1,2), alpha-(1,3) and alpha-(1,6) glycosidic linkages with lower efficiency, whereas beta glycosidic linkages are usually not hydrolyzed (PubMed:27480812)

Protein Sequence

10 MARKKLKKFT 20 TLEIVLSVLL 30 LVLFIISIVL 40 IVLLAKESLK 50 STAPDPGTTG 60 TPDPGTTGTP 70 DPGTTGTTHA 80 RTTGPPDPGT 90 TGTTPVSAEC 100 PVVNELERIN 110 CIPDQPPTKA 120 TCDQRGCCWN 130 PQGAVSVPWC 140 YYSKNHSYHV 150 EGNLVNTNAG 160 FTARLKNLPS 170 SPVFGSNVDN 180 VLLTAEYQTS 190 NRFHFKLTDQ 200 TNNRFEVPHE 210 HVQSFSGNAA 220 ASLTYQVEIS 230 RQPFSIKVTR 240 RSNNRVLFDS 250 SIGPLLFADQ 260 FLQLSTRLPS 270 TNVYGLGEHV 280 HQQYRHDMNW 290 KTWPIFNRDT 300 TPNGNGTNLY 310 GAQTFFLCLE 320 DASGLSFGVF 330 LMNSNAMEVV 340 LQPAPAITYR 350 TIGGILDFYV 360 FLGNTPEQVV 370 QEYLELIGRP 380 ALPSYWALGF 390 HLSRYEYGTL 400 DNMREVVERN 410 RAAQLPYDVQ 420 HADIDYMDER 430 RDFTYDSVDF 440 KGFPEFVNEL 450 HNNGQKLVII 460 VDPAISNNSS 470 SSKPYGPYDR 480 GSDMKIWVNS 490 SDGVTPLIGE 500 VWPGQTVFPD 510 YTNPNCAVWW 520 TKEFELFHNQ 530 VEFDGIWIDM 540 NEVSNFVDGS 550 VSGCSTNNLN 560 NPPFTPRILD 570 GYLFCKTLCM 580 DAVQHWGKQY 590 DIHNLYGYSM 600 AVATAEAAKT 610 VFPNKRSFIL 620 TRSTFAGSGK 630 FAAHWLGDNT 640 ATWDDLRWSI 650 PGVLEFNLFG 660 IPMVGPDICG 670 FALDTPEELC 680 RRWMQLGAFY 690 PFSRNHNGQG 700 YKDQDPASFG 710 ADSLLLNSSR 720 HYLNIRYTLL 730 PYLYTLFFRA 740 HSRGDTVARP 750 LLHEFYEDNS 760 TWDVHQQFLW 770 GPGLLITPVL 780 DEGAEKVMAY 790 VPDAVWYDYE 800 TGSQVRWRKQ 810 KVEMELPGDK 820 IGLHLRGGYI 830 FPTQQPNTTT 840 LASRKNPLGL 850 IIALDENKEA 860 KGELFWDNGE 870 TKDTVANKVY 880 LLCEFSVTQN 890 RLEVNISQST 900 YKDPNNLAFN 910 EIKILGTEEP 920 SNVTVKHNGV 930 PSQTSPTVTY 940 DSNLKVAIIT 950 DIDLLLGEAY 960 TVEWSIKIRD 970 EEKIDCYPDE 980 NGASAENCTA 990 RGCIWEASNS 1000 SGVPFCYFVN 1010 DLYSVSDVQY 1020 NSHGATADIS 1030 LKSSVYANAF 1040 PSTPVNPLRL 1050 DVTYHKNEML 1060 QFKIYDPNKN 1070 RYEVPVPLNI 1080 PSMPSSTPEG 1090 QLYDVLIKKN 1100 PFGIEIRRKS 1110 TGTIIWDSQL 1120 LGFTFSDMFI 1130 RISTRLPSKY 1140 LYGFGETEHR 1150 SYRRDLEWHT 1160 WGMFSRDQPP 1170 GYKKNSYGVH 1180 PYYMGLEEDG 1190 SAHGVLLLNS 1200 NAMDVTFQPL 1210 PALTYRTTGG 1220 VLDFYVFLGP 1230 TPELVTQQYT 1240 ELIGRPVMVP 1250 YWSLGFQLCR 1260 YGYQNDSEIA 1270 SLYDEMVAAQ 1280 IPYDVQYSDI 1290 DYMERQLDFT 1300 LSPKFAGFPA 1310 LINRMKADGM 1320 RVILILDPAI 1330 SGNETQPYPA 1340 FTRGVEDDVF 1350 IKYPNDGDIV 1360 WGKVWPDFPD 1370 VVVNGSLDWD 1380 SQVELYRAYV 1390 AFPDFFRNST 1400 AKWWKREIEE 1410 LYNNPQNPER 1420 SLKFDGMWID 1430 MNEPSSFVNG 1440 AVSPGCRDAS 1450 LNHPPYMPHL 1460 ESRDRGLSSK 1470 TLCMESQQIL 1480 PDGSLVQHYN 1490 VHNLYGWSQT 1500 RPTYEAVQEV 1510 TGQRGVVITR 1520 STFPSSGRWA 1530 GHWLGDNTAA 1540 WDQLKKSIIG 1550 MMEFSLFGIS 1560 YTGADICGFF 1570 QDAEYEMCVR 1580 WMQLGAFYPF 1590 SRNHNTIGTR 1600 RQDPVSWDAA 1610 FVNISRNVLQ 1620 TRYTLLPYLY 1630 TLMQKAHTEG 1640 VTVVRPLLHE 1650 FVSDQVTWDI 1660 DSQFLLGPAF 1670 LVSPVLERNA 1680 RNVTAYFPRA 1690 RWYDYYTGVD 1700 INARGEWKTL 1710 PAPLDHINLH 1720 VRGGYILPWQ 1730 EPALNTHLSR 1740 KNPLGLIIAL 1750 DENKEAKGEL 1760 FWDDGQTKDT 1770 VAKKVYLLCE 1780 FSVTQNHLEV 1790 TISQSTYKDP 1800 NNLAFNEIKI 1810 LGMEEPSNVT 1820 VKHNGVPSQT 1830 SPTVTYDSNL 1840 KVAIITDINL 1850 FLGEAYTVEW 1860 SIKIRDEEKI 1870 DCYPDENGDS 1880 AENCTARGCI 1890 WEASNSSGVP 1900 FCYFVNDLYS 1910 VSDVQYNSHG 1920 ATADISLKSS 1930 VHANAFPSTP 1940 VNPLRLDVTY 1950 HKNEMLQFKI 1960 YDPNNNRYEV 1970 PVPLNIPSVP 1980 SSTPEGQLYD 1990 VLIKKNPFGI 2000 EIRRKSTGTI 2010 IWDSQLLGFT 2020 FNDMFIRIST 2030 RLPSKYLYGF 2040 GETEHTSYRR 2050 DLEWHTWGMF 2060 SRDQPPGYKK 2070 NSYGVHPYYM 2080 GLEEDGSAHG 2090 VLLLNSNAMD 2100 VTFQPLPALT 2110 YRTTGGVLDF 2120 YVFLGPTPEL 2130 VTQQYTELIG 2140 RPVMVPYWSL 2150 GFQLCRYGYQ 2160 NDSEISSLYD 2170 EMVAAQIPYD 2180 VQYSDIDYME 2190 RQLDFTLSPK 2200 FAGFPALINR 2210 MKADGMRVIL 2220 ILDPAISGNE 2230 TQPYPAFTRG 2240 VEDDVFIKYP 2250 NDGDIVWGKV 2260 WPDFPDVVVN 2270 GSLDWDSQVE 2280 LYRAYVAFPD 2290 FFRNSTAKWW 2300 KREIEELYNN 2310 PQNPERSLKF 2320 DGMWIDMNEP 2330 SSFVNGAVSP 2340 GCRDASLNHP 2350 PYMPYLESRD 2360 RGLSSKTLCM 2370 ESQQILPDGS 2380 PVQHYNVHNL 2390 YGWSQTRPTY 2400 EAVQEVTGQR 2410 GVVITRSTFP 2420 SSGRWAGHWL 2430 GDNTAAWDQL 2440 KKSIIGMMEF 2450 SLFGISYTGA 2460 DICGFFQDAE 2470 YEMCVRWMQL 2480 GAFYPFSRNH 2490 NTIGTRRQDP 2500 VSWDVAFVNI 2510 SRTVLQTRYT 2520 LLPYLYTLMH 2530 KAHTEGVTVV 2540 RPLLHEFVSD 2550 QVTWDIDSQF 2560 LLGPAFLVSP 2570 VLERNARNVT 2580 AYFPRARWYD 2590 YYTGVDINAR 2600 GEWKTLPAPL 2610 DHINLHVRGG 2620 YILPWQEPAL 2630 NTHLSRQKFM 2640 GFKIALDDEG 2650 TAGGWLFWDD 2660 GQSIDTYGKG 2670 LYYLASFSAS 2680 QNTMQSHIIF 2690 NNYITGTNPL 2700 KLGYIEIWGV 2710 GSVPVTSVSI 2720 SVSGMVITPS 2730 FNNDPTTQVL 2740 SIDVTDRNIS 2750 LHNFTSLTWI STL

Gene Ontology

Classification GO ID Description
Cellular Component GO:0016324 apical plasma membrane
Cellular Component GO:0070062 extracellular exosome
Cellular Component GO:0101003 ficolin-1-rich granule membrane
Cellular Component GO:0005886 plasma membrane
Cellular Component GO:0070821 tertiary granule membrane
Molecular Function GO:0004558 alpha-1,4-glucosidase activity
Molecular Function GO:0016160 amylase activity
Molecular Function GO:0030246 carbohydrate binding
Molecular Function GO:0003824 catalytic activity
Molecular Function GO:0004574 oligo-1,6-glucosidase activity
Biological Process GO:1901027 dextrin catabolic process
Biological Process GO:0000025 maltose catabolic process
Biological Process GO:0005983 starch catabolic process

Reference

[1] Cheng Z, Huang H, Li M, Chen Y. Proteomic analysis identifies PFKP lactylation in SW480 colon cancer cells.. iScience 27(1):108645. 2024 Jan 19. PMID: 38155775.