Overview
| Uniprot ID | O43451 |
| Protein Name | Maltase-glucoamylase |
| Gene Name | MGAM |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 848 |
IIALDENKEAKGELF |
Function
Alpha-(1,4) exo-glucosidase involved in breakdown of dietary starch oligosaccharides in small intestine. Cleaves the non-reducing alpha-(1,4)-linked glucose residue in linear dextrins with retention of anomeric center stereochemistry (PubMed:12547908, PubMed:18036614, PubMed:18356321, PubMed:22058037, PubMed:27480812). Mainly hydrolyzes short length oligomaltoses having two to seven glucose residues (PubMed:12547908, PubMed:18036614, PubMed:18356321, PubMed:22058037, PubMed:27480812). Can cleave alpha-(1,2), alpha-(1,3) and alpha-(1,6) glycosidic linkages with lower efficiency, whereas beta glycosidic linkages are usually not hydrolyzed (PubMed:27480812)
Protein Sequence
10
MARKKLKKFT
20
TLEIVLSVLL
30
LVLFIISIVL
40
IVLLAKESLK
50
STAPDPGTTG
60
TPDPGTTGTP
70
DPGTTGTTHA
80
RTTGPPDPGT
90
TGTTPVSAEC
100
PVVNELERIN
110
CIPDQPPTKA
120
TCDQRGCCWN
130
PQGAVSVPWC
140
YYSKNHSYHV
150
EGNLVNTNAG
160
FTARLKNLPS
170
SPVFGSNVDN
180
VLLTAEYQTS
190
NRFHFKLTDQ
200
TNNRFEVPHE
210
HVQSFSGNAA
220
ASLTYQVEIS
230
RQPFSIKVTR
240
RSNNRVLFDS
250
SIGPLLFADQ
260
FLQLSTRLPS
270
TNVYGLGEHV
280
HQQYRHDMNW
290
KTWPIFNRDT
300
TPNGNGTNLY
310
GAQTFFLCLE
320
DASGLSFGVF
330
LMNSNAMEVV
340
LQPAPAITYR
350
TIGGILDFYV
360
FLGNTPEQVV
370
QEYLELIGRP
380
ALPSYWALGF
390
HLSRYEYGTL
400
DNMREVVERN
410
RAAQLPYDVQ
420
HADIDYMDER
430
RDFTYDSVDF
440
KGFPEFVNEL
450
HNNGQKLVII
460
VDPAISNNSS
470
SSKPYGPYDR
480
GSDMKIWVNS
490
SDGVTPLIGE
500
VWPGQTVFPD
510
YTNPNCAVWW
520
TKEFELFHNQ
530
VEFDGIWIDM
540
NEVSNFVDGS
550
VSGCSTNNLN
560
NPPFTPRILD
570
GYLFCKTLCM
580
DAVQHWGKQY
590
DIHNLYGYSM
600
AVATAEAAKT
610
VFPNKRSFIL
620
TRSTFAGSGK
630
FAAHWLGDNT
640
ATWDDLRWSI
650
PGVLEFNLFG
660
IPMVGPDICG
670
FALDTPEELC
680
RRWMQLGAFY
690
PFSRNHNGQG
700
YKDQDPASFG
710
ADSLLLNSSR
720
HYLNIRYTLL
730
PYLYTLFFRA
740
HSRGDTVARP
750
LLHEFYEDNS
760
TWDVHQQFLW
770
GPGLLITPVL
780
DEGAEKVMAY
790
VPDAVWYDYE
800
TGSQVRWRKQ
810
KVEMELPGDK
820
IGLHLRGGYI
830
FPTQQPNTTT
840
LASRKNPLGL
850
IIALDENKEA
860
KGELFWDNGE
870
TKDTVANKVY
880
LLCEFSVTQN
890
RLEVNISQST
900
YKDPNNLAFN
910
EIKILGTEEP
920
SNVTVKHNGV
930
PSQTSPTVTY
940
DSNLKVAIIT
950
DIDLLLGEAY
960
TVEWSIKIRD
970
EEKIDCYPDE
980
NGASAENCTA
990
RGCIWEASNS
1000
SGVPFCYFVN
1010
DLYSVSDVQY
1020
NSHGATADIS
1030
LKSSVYANAF
1040
PSTPVNPLRL
1050
DVTYHKNEML
1060
QFKIYDPNKN
1070
RYEVPVPLNI
1080
PSMPSSTPEG
1090
QLYDVLIKKN
1100
PFGIEIRRKS
1110
TGTIIWDSQL
1120
LGFTFSDMFI
1130
RISTRLPSKY
1140
LYGFGETEHR
1150
SYRRDLEWHT
1160
WGMFSRDQPP
1170
GYKKNSYGVH
1180
PYYMGLEEDG
1190
SAHGVLLLNS
1200
NAMDVTFQPL
1210
PALTYRTTGG
1220
VLDFYVFLGP
1230
TPELVTQQYT
1240
ELIGRPVMVP
1250
YWSLGFQLCR
1260
YGYQNDSEIA
1270
SLYDEMVAAQ
1280
IPYDVQYSDI
1290
DYMERQLDFT
1300
LSPKFAGFPA
1310
LINRMKADGM
1320
RVILILDPAI
1330
SGNETQPYPA
1340
FTRGVEDDVF
1350
IKYPNDGDIV
1360
WGKVWPDFPD
1370
VVVNGSLDWD
1380
SQVELYRAYV
1390
AFPDFFRNST
1400
AKWWKREIEE
1410
LYNNPQNPER
1420
SLKFDGMWID
1430
MNEPSSFVNG
1440
AVSPGCRDAS
1450
LNHPPYMPHL
1460
ESRDRGLSSK
1470
TLCMESQQIL
1480
PDGSLVQHYN
1490
VHNLYGWSQT
1500
RPTYEAVQEV
1510
TGQRGVVITR
1520
STFPSSGRWA
1530
GHWLGDNTAA
1540
WDQLKKSIIG
1550
MMEFSLFGIS
1560
YTGADICGFF
1570
QDAEYEMCVR
1580
WMQLGAFYPF
1590
SRNHNTIGTR
1600
RQDPVSWDAA
1610
FVNISRNVLQ
1620
TRYTLLPYLY
1630
TLMQKAHTEG
1640
VTVVRPLLHE
1650
FVSDQVTWDI
1660
DSQFLLGPAF
1670
LVSPVLERNA
1680
RNVTAYFPRA
1690
RWYDYYTGVD
1700
INARGEWKTL
1710
PAPLDHINLH
1720
VRGGYILPWQ
1730
EPALNTHLSR
1740
KNPLGLIIAL
1750
DENKEAKGEL
1760
FWDDGQTKDT
1770
VAKKVYLLCE
1780
FSVTQNHLEV
1790
TISQSTYKDP
1800
NNLAFNEIKI
1810
LGMEEPSNVT
1820
VKHNGVPSQT
1830
SPTVTYDSNL
1840
KVAIITDINL
1850
FLGEAYTVEW
1860
SIKIRDEEKI
1870
DCYPDENGDS
1880
AENCTARGCI
1890
WEASNSSGVP
1900
FCYFVNDLYS
1910
VSDVQYNSHG
1920
ATADISLKSS
1930
VHANAFPSTP
1940
VNPLRLDVTY
1950
HKNEMLQFKI
1960
YDPNNNRYEV
1970
PVPLNIPSVP
1980
SSTPEGQLYD
1990
VLIKKNPFGI
2000
EIRRKSTGTI
2010
IWDSQLLGFT
2020
FNDMFIRIST
2030
RLPSKYLYGF
2040
GETEHTSYRR
2050
DLEWHTWGMF
2060
SRDQPPGYKK
2070
NSYGVHPYYM
2080
GLEEDGSAHG
2090
VLLLNSNAMD
2100
VTFQPLPALT
2110
YRTTGGVLDF
2120
YVFLGPTPEL
2130
VTQQYTELIG
2140
RPVMVPYWSL
2150
GFQLCRYGYQ
2160
NDSEISSLYD
2170
EMVAAQIPYD
2180
VQYSDIDYME
2190
RQLDFTLSPK
2200
FAGFPALINR
2210
MKADGMRVIL
2220
ILDPAISGNE
2230
TQPYPAFTRG
2240
VEDDVFIKYP
2250
NDGDIVWGKV
2260
WPDFPDVVVN
2270
GSLDWDSQVE
2280
LYRAYVAFPD
2290
FFRNSTAKWW
2300
KREIEELYNN
2310
PQNPERSLKF
2320
DGMWIDMNEP
2330
SSFVNGAVSP
2340
GCRDASLNHP
2350
PYMPYLESRD
2360
RGLSSKTLCM
2370
ESQQILPDGS
2380
PVQHYNVHNL
2390
YGWSQTRPTY
2400
EAVQEVTGQR
2410
GVVITRSTFP
2420
SSGRWAGHWL
2430
GDNTAAWDQL
2440
KKSIIGMMEF
2450
SLFGISYTGA
2460
DICGFFQDAE
2470
YEMCVRWMQL
2480
GAFYPFSRNH
2490
NTIGTRRQDP
2500
VSWDVAFVNI
2510
SRTVLQTRYT
2520
LLPYLYTLMH
2530
KAHTEGVTVV
2540
RPLLHEFVSD
2550
QVTWDIDSQF
2560
LLGPAFLVSP
2570
VLERNARNVT
2580
AYFPRARWYD
2590
YYTGVDINAR
2600
GEWKTLPAPL
2610
DHINLHVRGG
2620
YILPWQEPAL
2630
NTHLSRQKFM
2640
GFKIALDDEG
2650
TAGGWLFWDD
2660
GQSIDTYGKG
2670
LYYLASFSAS
2680
QNTMQSHIIF
2690
NNYITGTNPL
2700
KLGYIEIWGV
2710
GSVPVTSVSI
2720
SVSGMVITPS
2730
FNNDPTTQVL
2740
SIDVTDRNIS
2750
LHNFTSLTWI
STL
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0016324 |
apical plasma membrane |
| Cellular Component |
GO:0070062 |
extracellular exosome |
| Cellular Component |
GO:0101003 |
ficolin-1-rich granule membrane |
| Cellular Component |
GO:0005886 |
plasma membrane |
| Cellular Component |
GO:0070821 |
tertiary granule membrane |
| Molecular Function |
GO:0004558 |
alpha-1,4-glucosidase activity |
| Molecular Function |
GO:0016160 |
amylase activity |
| Molecular Function |
GO:0030246 |
carbohydrate binding |
| Molecular Function |
GO:0003824 |
catalytic activity |
| Molecular Function |
GO:0004574 |
oligo-1,6-glucosidase activity |
| Biological Process |
GO:1901027 |
dextrin catabolic process |
| Biological Process |
GO:0000025 |
maltose catabolic process |
| Biological Process |
GO:0005983 |
starch catabolic process |
Reference
[1] Cheng Z, Huang H, Li M, Chen Y. Proteomic analysis identifies PFKP lactylation in SW480 colon cancer cells.. iScience 27(1):108645. 2024 Jan 19. PMID: 38155775.