Search Results

Overview

Uniprot ID	O43488
Protein Name	Aflatoxin B1 aldehyde reductase member 2
Gene Name	AKR7A2
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
128	SQLETSLKRLQCPQV
245	KYEDKDGKQPVGRFF

Function

Catalyzes the NADPH-dependent reduction of succinic semialdehyde to gamma-hydroxybutyrate. May have an important role in producing the neuromodulator gamma-hydroxybutyrate (GHB). Has broad substrate specificity. Has NADPH-dependent aldehyde reductase activity towards 2-carboxybenzaldehyde, 2-nitrobenzaldehyde and pyridine-2-aldehyde (in vitro). Can reduce 1,2-naphthoquinone and 9,10-phenanthrenequinone (in vitro). Can reduce the dialdehyde protein-binding form of aflatoxin B1 (AFB1) to the non-binding AFB1 dialcohol. May be involved in protection of liver against the toxic and carcinogenic effects of AFB1, a potent hepatocarcinogen

Protein Sequence

10 MLSAASRVVS 20 RAAVHCALRS 30 PPPEARALAM 40 SRPPPPRVAS 50 VLGTMEMGRR 60 MDAPASAAAV 70 RAFLERGHTE 80 LDTAFMYSDG 90 QSETILGGLG 100 LGLGGGDCRV 110 KIATKANPWD 120 GKSLKPDSVR 130 SQLETSLKRL 140 QCPQVDLFYL 150 HAPDHGTPVE 160 ETLHACQRLH 170 QEGKFVELGL 180 SNYASWEVAE 190 ICTLCKSNGW 200 ILPTVYQGMY 210 NATTRQVETE 220 LFPCLRHFGL 230 RFYAYNPLAG 240 GLLTGKYKYE 250 DKDGKQPVGR 260 FFGNSWAETY 270 RNRFWKEHHF 280 EAIALVEKAL 290 QAAYGASAPS 300 VTSAALRWMY 310 HHSQLQGAHG 320 DAVILGMSSL 330 EQLEQNLAAT 340 EEGPLEPAVV 350 DAFNQAWHLV AHECPNYFR

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005737	cytoplasm
Cellular Component	GO:0005829	cytosol
Cellular Component	GO:0070062	extracellular exosome
Cellular Component	GO:0005794	Golgi apparatus
Cellular Component	GO:0005739	mitochondrion
Molecular Function	GO:0008106	alcohol dehydrogenase (NADP+) activity
Molecular Function	GO:0004032	aldose reductase (NADPH) activity
Molecular Function	GO:0009055	electron transfer activity
Molecular Function	GO:0019119	phenanthrene-9,10-epoxide hydrolase activity
Biological Process	GO:0006081	aldehyde metabolic process
Biological Process	GO:0005975	carbohydrate metabolic process
Biological Process	GO:0044597	daunorubicin metabolic process
Biological Process	GO:0044598	doxorubicin metabolic process
Biological Process	GO:0006629	lipid metabolic process

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.