Search Results

Overview

Uniprot IDO43491
Protein NameBand 4.1-like protein 2
Gene NameEPB41L2
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
447 FAWPKILKISYKRSN
451 KILKISYKRSNFYIK
486 RAAKRLWKVCVEHHT
507 PEQPPKAKFLTLGSK
601 REVRSPTKAPHLQLI
84 FIPPWLKKQKSYTLV
892 QRTEISTKEVPIVQT
946 THITKTVKGGISETR
995 VTRVVVHKETELAEE

Function

Required for dynein-dynactin complex and NUMA1 recruitment at the mitotic cell cortex during anaphase (PubMed:23870127)

Protein Sequence

10 MTTEVGSVSE 20 VKKDSSQLGT 30 DATKEKPKEV 40 AENQQNQSSD 50 PEEEKGSQPP 60 PAAESQSSLR 70 RQKREKETSE 80 SRGISRFIPP 90 WLKKQKSYTL 100 VVAKDGGDKK 110 EPTQAVVEEQ 120 VLDKEEPLPE 130 EQRQAKGDAE 140 EMAQKKQEIK 150 VEVKEEKPSV 160 SKEEKPSVSK 170 VEMQPTELVS 180 KEREEKVKET 190 QEDKLEGGAA 200 KRETKEVQTN 210 ELKAEKASQK 220 VTKKTKTVQC 230 KVTLLDGTEY 240 SCDLEKHAKG 250 QVLFDKVCEH 260 LNLLEKDYFG 270 LLFQESPEQK 280 NWLDPAKEIK 290 RQLRNLPWLF 300 TFNVKFYPPD 310 PSQLTEDITR 320 YFLCLQLRQD 330 IASGRLPCSF 340 VTHALLGSYT 350 LQAELGDYDP 360 EEHGSIDLSE 370 FQFAPTQTKE 380 LEEKVAELHK 390 THRGLSPAQA 400 DSQFLENAKR 410 LSMYGVDLHH 420 AKDSEGVDIK 430 LGVCANGLLI 440 YKDRLRINRF 450 AWPKILKISY 460 KRSNFYIKVR 470 PAELEQFEST 480 IGFKLPNHRA 490 AKRLWKVCVE 500 HHTFYRLVSP 510 EQPPKAKFLT 520 LGSKFRYSGR 530 TQAQTRQAST 540 LIDRPAPHFE 550 RTSSKRVSRS 560 LDGAPIGVMD 570 QSLMKDFPGA 580 AGEISAYGPG 590 LVSIAVVQDG 600 DGRREVRSPT 610 KAPHLQLIEG 620 KKNSLRVEGD 630 NIYVRHSNLM 640 LEELDKAQED 650 ILKHQASISE 660 LKRNFMESTP 670 EPRPNEWEKR 680 RITPLSLQTQ 690 GSSHETLNIV 700 EEKKRAEVGK 710 DERVITEEMN 720 GKEISPGSGP 730 GEIRKVEPVT 740 QKDSTSLSSE 750 SSSSSSESEE 760 EDVGEYRPHH 770 RVTEGTIREE 780 QEYEEEVEEE 790 PRPAAKVVER 800 EEAVPEASPV 810 TQAGASVITV 820 ETVIQENVGA 830 QKIPGEKSVH 840 EGALKQDMGE 850 EAEEEPQKVN 860 GEVSHVDIDV 870 LPQIICCSEP 880 PVVKTEMVTI 890 SDASQRTEIS 900 TKEVPIVQTE 910 TKTITYESPQ 920 IDGGAGGDSG 930 TLLTAQTITS 940 ESVSTTTTTH 950 ITKTVKGGIS 960 ETRIEKRIVI 970 TGDGDIDHDQ 980 ALAQAIREAR 990 EQHPDMSVTR 1000 VVVHKETELA EEGED

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005938 cell cortex
Cellular Component GO:0030054 cell junction
Cellular Component GO:0005856 cytoskeleton
Cellular Component GO:0005829 cytosol
Cellular Component GO:0070062 extracellular exosome
Cellular Component GO:0005925 focal adhesion
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005886 plasma membrane
Cellular Component GO:0008091 spectrin
Molecular Function GO:0003779 actin binding
Molecular Function GO:0042731 PH domain binding
Molecular Function GO:0030507 spectrin binding
Molecular Function GO:0005198 structural molecule activity
Biological Process GO:0031032 actomyosin structure organization
Biological Process GO:0051301 cell division
Biological Process GO:0030866 cortical actin cytoskeleton organization
Biological Process GO:1904778 positive regulation of protein localization to cell cortex

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Yang YH, Wang QC, Kong J, Yang JT, Liu JF. Global profiling of lysine lactylation in human lungs.. Proteomics 23(15):e2200437. 2023 Aug. PMID: 37170646.

[3] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[4] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.

[5] Chao L, Xu Y, Yang Y, Ao X, Liang J. Identification of lactylation-related biomarkers for diagnosis, prognosis, and treatment responsiveness in triple-negative breast cancer.. World J Surg Oncol 24(1):77. 2026 Jan 22. PMID: 41566505.

[6] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.