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Overview

Uniprot IDO43556
Protein NameEpsilon-sarcoglycan
Gene NameSGCE
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
125 PTAENVGKPTIIEIT

Function

Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix

Protein Sequence

10 MQLPRWWELG 20 DPCAWTGQGR 30 GTRRMSPATT 40 GTFLLTVYSI 50 FSKVHSDRNV 60 YPSAGVLFVH 70 VLEREYFKGE 80 FPPYPKPGEI 90 SNDPITFNTN 100 LMGYPDRPGW 110 LRYIQRTPYS 120 DGVLYGSPTA 130 ENVGKPTIIE 140 ITAYNRRTFE 150 TARHNLIINI 160 MSAEDFPLPY 170 QAEFFIKNMN 180 VEEMLASEVL 190 GDFLGAVKNV 200 WQPERLNAIN 210 ITSALDRGGR 220 VPLPINDLKE 230 GVYVMVGADV 240 PFSSCLREVE 250 NPQNQLRCSQ 260 EMEPVITCDK 270 KFRTQFYIDW 280 CKISLVDKTK 290 QVSTYQEVIR 300 GEGILPDGGE 310 YKPPSDSLKS 320 RDYYTDFLIT 330 LAVPSAVALV 340 LFLILAYIMC 350 CRREGVEKRN 360 MQTPDIQLVH 370 HSAIQKSTKE 380 LRDMSKNREI 390 AWPLSTLPVF 400 HPVTGEIIPP 410 LHTDNYDSTN 420 MPLMQTQQNL 430 PHQTQIPQQQ TTGKWYP

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005856 cytoskeleton
Cellular Component GO:0032590 dendrite membrane
Cellular Component GO:0016010 dystrophin-associated glycoprotein complex
Cellular Component GO:0005789 endoplasmic reticulum membrane
Cellular Component GO:0005794 Golgi apparatus
Cellular Component GO:0000139 Golgi membrane
Cellular Component GO:0005886 plasma membrane
Cellular Component GO:0016012 sarcoglycan complex
Cellular Component GO:0042383 sarcolemma
Cellular Component GO:0045202 synapse
Biological Process GO:0007160 cell-matrix adhesion
Biological Process GO:0007517 muscle organ development
Biological Process GO:0099536 synaptic signaling

Reference

[1] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.