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Overview

Uniprot ID	O43583
Protein Name	Density-regulated protein
Gene Name	DENR
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
14	ESSGADCKGDPRNSA
22	GDPRNSAKLDADYPL

Function

Translation regulator forming a complex with MCTS1 to promote translation reinitiation. Translation reinitiation is the process where the small ribosomal subunit remains attached to the mRNA following termination of translation of a regulatory upstream ORF (uORF), and resume scanning on the same mRNA molecule to initiate translation of a downstream ORF, usually the main ORF (mORF). The MCTS1/DENR complex is pivotal to two linked mechanisms essential for translation reinitiation. Firstly, the dissociation of deacylated tRNAs from post-termination 40S ribosomal complexes during ribosome recycling. Secondly, the recruitment in an EIF2-independent manner of aminoacylated initiator tRNA to P site of 40S ribosomes for a new round of translation. This regulatory mechanism governs the translation of more than 150 genes which translation reinitiation is MCTS1/DENR complex-dependent

Protein Sequence

10 MAADISESSG 20 ADCKGDPRNS 30 AKLDADYPLR 40 VLYCGVCSLP 50 TEYCEYMPDV 60 AKCRQWLEKN 70 FPNEFAKLTV 80 ENSPKQEAGI 90 SEGQGTAGEE 100 EEKKKQKRGG 110 RGQIKQKKKT 120 VPQKVTIAKI 130 PRAKKKYVTR 140 VCGLATFEID 150 LKEAQRFFAQ 160 KFSCGASVTG 170 EDEIIIQGDF 180 TDDIIDVIQE 190 KWPEVDDDSI EDLGEVKK

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005737	cytoplasm
Molecular Function	GO:0003743	translation initiation factor activity
Biological Process	GO:0001731	formation of translation preinitiation complex
Biological Process	GO:0075522	IRES-dependent viral translational initiation
Biological Process	GO:0032790	ribosome disassembly
Biological Process	GO:0002188	translation reinitiation

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[3] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.