Search Results
Overview
| Uniprot ID | O43615 |
|---|---|
| Protein Name | Mitochondrial import inner membrane translocase subunit TIM44 |
| Gene Name | TIMM44 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 105 | QEARRKYKTIESETV |
| 121 | TSEVLRKKLGELTGT |
| 138 | ESLHEVSKSDLGRKI |
| 405 | VMVVRNPKGEVVEGD |
Function
Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner (By similarity). Recruits mitochondrial HSP70 to drive protein translocation into the matrix using ATP as an energy source (By similarity)
Protein Sequence
10
MAAAALRSGW
20
CRCPRRCLGS
30
GIQFLSSHNL
40
PHGSTYQMRR
50
PGGELPLSKS
60
YSSGNRKGFL
70
SGLLDNVKQE
80
LAKNKEMKES
90
IKKFRDEARR
100
LEESDVLQEA
110
RRKYKTIESE
120
TVRTSEVLRK
130
KLGELTGTVK
140
ESLHEVSKSD
150
LGRKIKEGVE
160
EAAKTAKQSA
170
ESVSKGGEKL
180
GRTAAFRALS
190
QGVESVKKEI
200
DDSVLGQTGP
210
YRRPQRLRKR
220
TEFAGDKFKE
230
EKVFEPNEEA
240
LGVVLHKDSK
250
WYQQWKDFKE
260
NNVVFNRFFE
270
MKMKYDESDN
280
AFIRASRALT
290
DKVTDLLGGL
300
FSKTEMSEVL
310
TEILRVDPAF
320
DKDRFLKQCE
330
NDIIPNVLEA
340
MISGELDILK
350
DWCYEATYSQ
360
LAHPIQQAKA
370
LGLQFHSRIL
380
DIDNVDLAMG
390
KMMEQGPVLI
400
ITFQAQLVMV
410
VRNPKGEVVE
420
GDPDKVLRML
430
YVWALCRDQD
440
ELNPYAAWRL
450
LDISASSTEQ
IL
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005743 | mitochondrial inner membrane |
| Cellular Component | GO:0005759 | mitochondrial matrix |
| Cellular Component | GO:0005739 | mitochondrion |
| Cellular Component | GO:0005744 | TIM23 mitochondrial import inner membrane translocase complex |
| Molecular Function | GO:0005524 | ATP binding |
| Molecular Function | GO:0051087 | protein-folding chaperone binding |
| Biological Process | GO:0006886 | intracellular protein transport |
| Biological Process | GO:0030150 | protein import into mitochondrial matrix |
| Biological Process | GO:0006626 | protein targeting to mitochondrion |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.