Search Results
Overview
| Uniprot ID | O43639 |
|---|---|
| Protein Name | Cytoplasmic protein NCK2 |
| Gene Name | NCK2 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 72 | GSLVKNLKDTLGLGK |
| 79 | KDTLGLGKTRRKTSA |
Function
Adapter protein which associates with tyrosine-phosphorylated growth factor receptors or their cellular substrates. Maintains low levels of EIF2S1 phosphorylation by promoting its dephosphorylation by PP1. Plays a role in ELK1-dependent transcriptional activation in response to activated Ras signaling
Protein Sequence
10
MTEEVIVIAK
20
WDYTAQQDQE
30
LDIKKNERLW
40
LLDDSKTWWR
50
VRNAANRTGY
60
VPSNYVERKN
70
SLKKGSLVKN
80
LKDTLGLGKT
90
RRKTSARDAS
100
PTPSTDAEYP
110
ANGSGADRIY
120
DLNIPAFVKF
130
AYVAEREDEL
140
SLVKGSRVTV
150
MEKCSDGWWR
160
GSYNGQIGWF
170
PSNYVLEEVD
180
EAAAESPSFL
190
SLRKGASLSN
200
GQGSRVLHVV
210
QTLYPFSSVT
220
EEELNFEKGE
230
TMEVIEKPEN
240
DPEWWKCKNA
250
RGQVGLVPKN
260
YVVVLSDGPA
270
LHPAHAPQIS
280
YTGPSSSGRF
290
AGREWYYGNV
300
TRHQAECALN
310
ERGVEGDFLI
320
RDSESSPSDF
330
SVSLKASGKN
340
KHFKVQLVDN
350
VYCIGQRRFH
360
TMDELVEHYK
370
KAPIFTSEHG
380
EKLYLVRALQ
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005783 | endoplasmic reticulum |
| Cellular Component | GO:0014069 | postsynaptic density |
| Cellular Component | GO:0012506 | vesicle membrane |
| Molecular Function | GO:0008093 | cytoskeletal anchor activity |
| Molecular Function | GO:0001784 | phosphotyrosine residue binding |
| Molecular Function | GO:0044877 | protein-containing complex binding |
| Molecular Function | GO:0030971 | receptor tyrosine kinase binding |
| Molecular Function | GO:0097110 | scaffold protein binding |
| Molecular Function | GO:0035591 | signaling adaptor activity |
| Molecular Function | GO:0030159 | signaling receptor complex adaptor activity |
| Biological Process | GO:0016477 | cell migration |
| Biological Process | GO:0048013 | ephrin receptor signaling pathway |
| Biological Process | GO:0007173 | epidermal growth factor receptor signaling pathway |
| Biological Process | GO:0008285 | negative regulation of cell population proliferation |
| Biological Process | GO:1903898 | negative regulation of PERK-mediated unfolded protein response |
| Biological Process | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| Biological Process | GO:0030838 | positive regulation of actin filament polymerization |
| Biological Process | GO:1902237 | positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway |
| Biological Process | GO:0042102 | positive regulation of T cell proliferation |
| Biological Process | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| Biological Process | GO:0036493 | positive regulation of translation in response to endoplasmic reticulum stress |
| Biological Process | GO:0036491 | regulation of translation initiation in response to endoplasmic reticulum stress |
| Biological Process | GO:0007172 | signal complex assembly |
| Biological Process | GO:0007165 | signal transduction |
| Biological Process | GO:0042110 | T cell activation |
Reference
[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.
[2] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.