Search Results

Overview

Uniprot ID	O43660
Protein Name	Pleiotropic regulator 1
Gene Name	PLRG1
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
180	KNSALMAKKAPTMPK
181	NSALMAKKAPTMPKP
510	SWKPEIIKRKRF***

Function

Involved in pre-mRNA splicing as component of the spliceosome (PubMed:28076346, PubMed:28502770). Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing (PubMed:11101529, PubMed:11544257). As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable)

Protein Sequence

10 MVEEVQKHSV 20 HTLVFRSLKR 30 THDMFVADNG 40 KPVPLDEESH 50 KRKMAIKLRN 60 EYGPVLHMPT 70 SKENLKEKGP 80 QNATDSYVHK 90 QYPANQGQEV 100 EYFVAGTHPY 110 PPGPGVALTA 120 DTKIQRMPSE 130 SAAQSLAVAL 140 PLQTKADANR 150 TAPSGSEYRH 160 PGASDRPQPT 170 AMNSIVMETG 180 NTKNSALMAK 190 KAPTMPKPQW 200 HPPWKLYRVI 210 SGHLGWVRCI 220 AVEPGNQWFV 230 TGSADRTIKI 240 WDLASGKLKL 250 SLTGHISTVR 260 GVIVSTRSPY 270 LFSCGEDKQV 280 KCWDLEYNKV 290 IRHYHGHLSA 300 VYGLDLHPTI 310 DVLVTCSRDS 320 TARIWDVRTK 330 ASVHTLSGHT 340 NAVATVRCQA 350 AEPQIITGSH 360 DTTIRLWDLV 370 AGKTRVTLTN 380 HKKSVRAVVL 390 HPRHYTFASG 400 SPDNIKQWKF 410 PDGSFIQNLS 420 GHNAIINTLT 430 VNSDGVLVSG 440 ADNGTMHLWD 450 WRTGYNFQRV 460 HAAVQPGSLD 470 SESGIFACAF 480 DQSESRLLTA 490 EADKTIKVYR 500 EDDTATEETH 510 PVSWKPEIIK RKRF

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0071013	catalytic step 2 spliceosome
Cellular Component	GO:0001650	fibrillar center
Cellular Component	GO:0031965	nuclear membrane
Cellular Component	GO:0016607	nuclear speck
Cellular Component	GO:0005654	nucleoplasm
Cellular Component	GO:0005634	nucleus
Cellular Component	GO:0000974	Prp19 complex
Cellular Component	GO:0071007	U2-type catalytic step 2 spliceosome
Biological Process	GO:0000398	mRNA splicing, via spliceosome

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[3] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[4] Bao Q, Wan N, He Z, Cao J, Yuan W et al.. Subcellular Proteomic Mapping of Lysine Lactylation.. J Am Soc Mass Spectrom 35(12):3221-3232. 2024 Dec 4. PMID: 39569522.

[5] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.