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Overview

Uniprot IDO43663
Protein NameProtein regulator of cytokinesis 1
Gene NamePRC1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
484 LAPNTPGKARKLNTT
534 AASTCSGKKTPRTGR
535 ASTCSGKKTPRTGRH

Function

Key regulator of cytokinesis that cross-links antiparrallel microtubules at an average distance of 35 nM. Essential for controlling the spatiotemporal formation of the midzone and successful cytokinesis. Required for KIF14 localization to the central spindle and midbody. Required to recruit PLK1 to the spindle. Stimulates PLK1 phosphorylation of RACGAP1 to allow recruitment of ECT2 to the central spindle. Acts as an oncogene for promoting bladder cancer cells proliferation, apoptosis inhibition and carcinogenic progression (PubMed:17409436)

Protein Sequence

10 MRRSEVLAEE 20 SIVCLQKALN 30 HLREIWELIG 40 IPEDQRLQRT 50 EVVKKHIKEL 60 LDMMIAEEES 70 LKERLIKSIS 80 VCQKELNTLC 90 SELHVEPFQE 100 EGETTILQLE 110 KDLRTQVELM 120 RKQKKERKQE 130 LKLLQEQDQE 140 LCEILCMPHY 150 DIDSASVPSL 160 EELNQFRQHV 170 TTLRETKASR 180 REEFVSIKRQ 190 IILCMEALDH 200 TPDTSFERDV 210 VCEDEDAFCL 220 SLENIATLQK 230 LLRQLEMQKS 240 QNEAVCEGLR 250 TQIRELWDRL 260 QIPEEEREAV 270 ATIMSGSKAK 280 VRKALQLEVD 290 RLEELKMQNM 300 KKVIEAIRVE 310 LVQYWDQCFY 320 SQEQRQAFAP 330 FCAEDYTESL 340 LQLHDAEIVR 350 LKNYYEVHKE 360 LFEGVQKWEE 370 TWRLFLEFER 380 KASDPNRFTN 390 RGGNLLKEEK 400 QRAKLQKMLP 410 KLEEELKARI 420 ELWEQEHSKA 430 FMVNGQKFME 440 YVAEQWEMHR 450 LEKERAKQER 460 QLKNKKQTET 470 EMLYGSAPRT 480 PSKRRGLAPN 490 TPGKARKLNT 500 TTMSNATANS 510 SIRPIFGGTV 520 YHSPVSRLPP 530 SGSKPVAAST 540 CSGKKTPRTG 550 RHGANKENLE 560 LNGSILSGGY 570 PGSAPLQRNF 580 SINSVASTYS 590 EFAKDPSLSD 600 SSTVGLQREL 610 SKASKSDATS 620 GILNSTNIQS

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005694 chromosome
Cellular Component GO:0070938 contractile ring
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005829 cytosol
Cellular Component GO:0015630 microtubule cytoskeleton
Cellular Component GO:0030496 midbody
Cellular Component GO:1990023 mitotic spindle midzone
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Cellular Component GO:0005819 spindle
Cellular Component GO:0005876 spindle microtubule
Cellular Component GO:0000922 spindle pole
Molecular Function GO:0042802 identical protein binding
Molecular Function GO:0019894 kinesin binding
Molecular Function GO:0008017 microtubule binding
Molecular Function GO:0019901 protein kinase binding
Biological Process GO:0051301 cell division
Biological Process GO:0000226 microtubule cytoskeleton organization
Biological Process GO:0000022 mitotic spindle elongation
Biological Process GO:0051256 mitotic spindle midzone assembly
Biological Process GO:0008284 positive regulation of cell population proliferation
Biological Process GO:0032465 regulation of cytokinesis

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[3] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[4] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.