Search Results
Overview
| Uniprot ID | O43676 |
|---|---|
| Protein Name | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 |
| Gene Name | NDUFB3 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 13 | GHEHGHHKMELPDYR |
| 34 | TPLETIQKKLAAKGL |
Function
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone
Protein Sequence
10
MAHEHGHEHG
20
HHKMELPDYR
30
QWKIEGTPLE
40
TIQKKLAAKG
50
LRDPWGRNEA
60
WRYMGGFAKS
70
VSFSDVFFKG
80
FKWGFAAFVV
90
AVGAEYYLES
LNKDKKHH
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005743 | mitochondrial inner membrane |
| Cellular Component | GO:0005739 | mitochondrion |
| Cellular Component | GO:0045271 | respiratory chain complex I |
| Molecular Function | GO:0008137 | NADH dehydrogenase (ubiquinone) activity |
| Biological Process | GO:0009060 | aerobic respiration |
| Biological Process | GO:0006120 | mitochondrial electron transport, NADH to ubiquinone |
| Biological Process | GO:0042776 | proton motive force-driven mitochondrial ATP synthesis |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.
[2] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.