Search Results
Overview
| Uniprot ID | O43680 |
|---|---|
| Protein Name | Transcription factor 21 |
| Gene Name | TCF21 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 77 | SGVSQEGKQVQRNAA |
Function
Involved in epithelial-mesenchymal interactions in kidney and lung morphogenesis that include epithelial differentiation and branching morphogenesis. May play a role in the specification or differentiation of one or more subsets of epicardial cell types
Protein Sequence
10
MSTGSLSDVE
20
DLQEVEMLEC
30
DGLKMDSNKE
40
FVTSNESTEE
50
SSNCENGSPQ
60
KGRGGLGKRR
70
KAPTKKSPLS
80
GVSQEGKQVQ
90
RNAANARERA
100
RMRVLSKAFS
110
RLKTTLPWVP
120
PDTKLSKLDT
130
LRLASSYIAH
140
LRQILANDKY
150
ENGYIHPVNL
160
TWPFMVAGKP
170
ESDLKEVVTA
SRLCGTTAS
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0000785 | chromatin |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0005667 | transcription regulator complex |
| Molecular Function | GO:0043425 | bHLH transcription factor binding |
| Molecular Function | GO:0001228 | DNA-binding transcription activator activity, RNA polymerase II-specific |
| Molecular Function | GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific |
| Molecular Function | GO:0001227 | DNA-binding transcription repressor activity, RNA polymerase II-specific |
| Molecular Function | GO:0070888 | E-box binding |
| Molecular Function | GO:0042826 | histone deacetylase binding |
| Molecular Function | GO:0050681 | nuclear androgen receptor binding |
| Molecular Function | GO:0046983 | protein dimerization activity |
| Molecular Function | GO:0000977 | RNA polymerase II transcription regulatory region sequence-specific DNA binding |
| Molecular Function | GO:1990837 | sequence-specific double-stranded DNA binding |
| Biological Process | GO:0001658 | branching involved in ureteric bud morphogenesis |
| Biological Process | GO:0014707 | branchiomeric skeletal muscle development |
| Biological Process | GO:0060435 | bronchiole development |
| Biological Process | GO:0032502 | developmental process |
| Biological Process | GO:0060539 | diaphragm development |
| Biological Process | GO:0006351 | DNA-templated transcription |
| Biological Process | GO:0048557 | embryonic digestive tract morphogenesis |
| Biological Process | GO:0030855 | epithelial cell differentiation |
| Biological Process | GO:0048732 | gland development |
| Biological Process | GO:0032835 | glomerulus development |
| Biological Process | GO:0001822 | kidney development |
| Biological Process | GO:0048286 | lung alveolus development |
| Biological Process | GO:0060425 | lung morphogenesis |
| Biological Process | GO:0060426 | lung vasculature development |
| Biological Process | GO:0072277 | metanephric glomerular capillary formation |
| Biological Process | GO:0072162 | metanephric mesenchymal cell differentiation |
| Biological Process | GO:0001763 | morphogenesis of a branching structure |
| Biological Process | GO:0060766 | negative regulation of androgen receptor signaling pathway |
| Biological Process | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| Biological Process | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| Biological Process | GO:0006357 | regulation of transcription by RNA polymerase II |
| Biological Process | GO:0048608 | reproductive structure development |
| Biological Process | GO:0060541 | respiratory system development |
| Biological Process | GO:0060021 | roof of mouth development |
| Biological Process | GO:0060008 | Sertoli cell differentiation |
| Biological Process | GO:0007530 | sex determination |
| Biological Process | GO:0048536 | spleen development |
| Biological Process | GO:0001657 | ureteric bud development |
| Biological Process | GO:0001944 | vasculature development |
Reference
[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.