Overview
| Uniprot ID | O43704 |
|---|
| Protein Name | Sulfotransferase 1B1 |
|---|
| Gene Name | SULT1B1 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 5 |
***MLSPKDILRKDL |
Function
Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of dopamine, small phenols such as 1-naphthol and p-nitrophenol and thyroid hormones, including 3,3'-diiodothyronine, triidothyronine (T3) and reverse triiodothyronine (rT3) (PubMed:28084139, PubMed:9443824, PubMed:9463486). May play a role in gut microbiota-host metabolic interaction. O-sulfonates 4-ethylphenol (4-EP), a dietary tyrosine-derived metabolite produced by gut bacteria. The product 4-EPS crosses the blood-brain barrier and may negatively regulate oligodendrocyte maturation and myelination, affecting the functional connectivity of different brain regions associated with the limbic system (PubMed:35165440)
Protein Sequence
10
MLSPKDILRK
20
DLKLVHGYPM
30
TCAFASNWEK
40
IEQFHSRPDD
50
IVIATYPKSG
60
TTWVSEIIDM
70
ILNDGDIEKC
80
KRGFITEKVP
90
MLEMTLPGLR
100
TSGIEQLEKN
110
PSPRIVKTHL
120
PTDLLPKSFW
130
ENNCKMIYLA
140
RNAKDVSVSY
150
YHFDLMNNLQ
160
PFPGTWEEYL
170
EKFLTGKVAY
180
GSWFTHVKNW
190
WKKKEEHPIL
200
FLYYEDMKEN
210
PKEEIKKIIR
220
FLEKNLNDEI
230
LDRIIHHTSF
240
EVMKDNPLVN
250
YTHLPTTVMD
260
HSKSPFMRKG
270
TAGDWKNYFT
280
VAQNEKFDAI
290
YETEMSKTAL
QFRTEI
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Biological Process |
GO:0009812 |
flavonoid metabolic process |
| Biological Process |
GO:0018958 |
phenol-containing compound metabolic process |
| Biological Process |
GO:0051923 |
sulfation |
| Biological Process |
GO:0042403 |
thyroid hormone metabolic process |
| Biological Process |
GO:0006805 |
xenobiotic metabolic process |
| Cellular Component |
GO:0005829 |
cytosol |
| Molecular Function |
GO:0004062 |
aryl sulfotransferase activity |
| Molecular Function |
GO:0008146 |
sulfotransferase activity |
| Biological Process |
GO:0050427 |
3'-phosphoadenosine 5'-phosphosulfate metabolic process |
| Biological Process |
GO:0006576 |
biogenic amine metabolic process |
| Biological Process |
GO:0030855 |
epithelial cell differentiation |
| Biological Process |
GO:0006068 |
ethanol catabolic process |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.