Search Results
Overview
| Uniprot ID | O43708 |
|---|---|
| Protein Name | Maleylacetoacetate isomerase |
| Gene Name | GSTZ1 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 177 | VANAERFKVDLTPYP |
| 191 | PTISSINKRLLVLEA |
| 32 | ALKGIDYKTVPINLI |
| 94 | RLLPQDPKKRASVRM |
Function
Bifunctional enzyme showing minimal glutathione-conjugating activity with ethacrynic acid and 7-chloro-4-nitrobenz-2-oxa-1,3-diazole and maleylacetoacetate isomerase activity. Also has low glutathione peroxidase activity with T-butyl and cumene hydroperoxides. Is able to catalyze the glutathione dependent oxygenation of dichloroacetic acid to glyoxylic acid
Protein Sequence
10
MQAGKPILYS
20
YFRSSCSWRV
30
RIALALKGID
40
YKTVPINLIK
50
DRGQQFSKDF
60
QALNPMKQVP
70
TLKIDGITIH
80
QSLAIIEYLE
90
EMRPTPRLLP
100
QDPKKRASVR
110
MISDLIAGGI
120
QPLQNLSVLK
130
QVGEEMQLTW
140
AQNAITCGFN
150
ALEQILQSTA
160
GIYCVGDEVT
170
MADLCLVPQV
180
ANAERFKVDL
190
TPYPTISSIN
200
KRLLVLEAFQ
210
VSHPCRQPDT
PTELRA
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005759 | mitochondrial matrix |
| Cellular Component | GO:0005739 | mitochondrion |
| Molecular Function | GO:0004602 | glutathione peroxidase activity |
| Molecular Function | GO:0004364 | glutathione transferase activity |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0016034 | maleylacetoacetate isomerase activity |
| Molecular Function | GO:0042803 | protein homodimerization activity |
| Biological Process | GO:1990748 | cellular detoxification |
| Biological Process | GO:0006749 | glutathione metabolic process |
| Biological Process | GO:0006559 | L-phenylalanine catabolic process |
| Biological Process | GO:0006572 | L-tyrosine catabolic process |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.