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Overview

Uniprot ID	O43741
Protein Name	5'-AMP-activated protein kinase subunit beta-2
Gene Name	PRKAB2
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
31	AGGHAPGKEHKIMVG

Function

Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3)

Protein Sequence

10 MGNTTSDRVS 20 GERHGAKAAR 30 SEGAGGHAPG 40 KEHKIMVGST 50 DDPSVFSLPD 60 SKLPGDKEFV 70 SWQQDLEDSV 80 KPTQQARPTV 90 IRWSEGGKEV 100 FISGSFNNWS 110 TKIPLIKSHN 120 DFVAILDLPE 130 GEHQYKFFVD 140 GQWVHDPSEP 150 VVTSQLGTIN 160 NLIHVKKSDF 170 EVFDALKLDS 180 MESSETSCRD 190 LSSSPPGPYG 200 QEMYAFRSEE 210 RFKSPPILPP 220 HLLQVILNKD 230 TNISCDPALL 240 PEPNHVMLNH 250 LYALSIKDSV 260 MVLSATHRYK 270 KKYVTTLLYK PI

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005737	cytoplasm
Cellular Component	GO:0005829	cytosol
Cellular Component	GO:0005788	endoplasmic reticulum lumen
Cellular Component	GO:0005654	nucleoplasm
Cellular Component	GO:0031588	nucleotide-activated protein kinase complex
Cellular Component	GO:0005634	nucleus
Molecular Function	GO:0019901	protein kinase binding
Biological Process	GO:0031669	cellular response to nutrient levels
Biological Process	GO:0006633	fatty acid biosynthetic process
Biological Process	GO:0120162	positive regulation of cold-induced thermogenesis
Biological Process	GO:0007165	signal transduction

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.