Overview
| Uniprot ID | O43772 |
|---|
| Protein Name | Mitochondrial carnitine/acylcarnitine carrier protein |
|---|
| Gene Name | SLC25A20 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 157 |
TGTLDCAKKLYQEFG |
| 170 |
FGIRGIYKGTVLTLM |
| 202 |
NIFTPEGKRVSELSA |
| 244 |
FQTAPPGKYPNGFRD |
Function
Mediates the electroneutral exchange of acylcarnitines (O-acyl-(R)-carnitine or L-acylcarnitine) of different acyl chain lengths (ranging from O-acetyl-(R)-carnitine to long-chain O-acyl-(R)-carnitines) with free carnitine ((R)-carnitine or L-carnitine) across the mitochondrial inner membrane, via a ping-pong mechanism (Probable) (PubMed:12892634, PubMed:18307102). Key player in the mitochondrial oxidation pathway, it translocates the fatty acids in the form of acylcarnitines into the mitochondrial matrix, where the carnitine palmitoyltransferase 2 (CPT-2) activates them to undergo fatty acid beta-oxidation (Probable). Catalyzes the unidirectional transport (uniport) of carnitine at lower rates than the antiport (exchange) (PubMed:18307102)
Protein Sequence
10
MADQPKPISP
20
LKNLLAGGFG
30
GVCLVFVGHP
40
LDTVKVRLQT
50
QPPSLPGQPP
60
MYSGTFDCFR
70
KTLFREGITG
80
LYRGMAAPII
90
GVTPMFAVCF
100
FGFGLGKKLQ
110
QKHPEDVLSY
120
PQLFAAGMLS
130
GVFTTGIMTP
140
GERIKCLLQI
150
QASSGESKYT
160
GTLDCAKKLY
170
QEFGIRGIYK
180
GTVLTLMRDV
190
PASGMYFMTY
200
EWLKNIFTPE
210
GKRVSELSAP
220
RILVAGGIAG
230
IFNWAVAIPP
240
DVLKSRFQTA
250
PPGKYPNGFR
260
DVLRELIRDE
270
GVTSLYKGFN
280
AVMIRAFPAN
290
AACFLGFEVA
300
MKFLNWATPN
L
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005740 |
mitochondrial envelope |
| Cellular Component |
GO:0005743 |
mitochondrial inner membrane |
| Cellular Component |
GO:0005739 |
mitochondrion |
| Molecular Function |
GO:0005476 |
carnitine:O-acyl-L-carnitine antiporter activity |
| Molecular Function |
GO:0015227 |
O-acyl-L-carnitine transmembrane transporter activity |
| Biological Process |
GO:0006853 |
carnitine shuttle |
| Biological Process |
GO:1902603 |
carnitine transmembrane transport |
| Biological Process |
GO:0006839 |
mitochondrial transport |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.