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Overview

Uniprot IDO43815
Protein NameStriatin
Gene NameSTRN
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
270 TSTIVRKKALPDSGE
353 VKRPNRSKLQDMLAN
500 QKTAPAKKSTSLDVE

Function

Calmodulin-binding scaffolding protein which is the center of the striatin-interacting phosphatase and kinase (STRIPAK) complexes (PubMed:18782753). STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling. Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation (Probable)

Protein Sequence

10 MDEQAGPGVF 20 FSNNHPGAGG 30 AKGLGPLAEA 40 AAAGDGAAAA 50 GAARAQYSLP 60 GILHFLQHEW 70 ARFEVERAQW 80 EVERAELQAQ 90 IAFLQGERKG 100 QENLKKDLVR 110 RIKMLEYALK 120 QERAKYHKLK 130 YGTELNQGDM 140 KPPSYDSDEG 150 NETEVQPQQN 160 SQLMWKQGRQ 170 LLRQYLQEVG 180 YTDTILDVKS 190 KRVRALLGFS 200 SDVTDREDDK 210 NQDSVVNGTE 220 AEVKETAMIA 230 KSELTDSASV 240 LDNFKFLESA 250 AADFSDEDED 260 DDVDGREKSV 270 IDTSTIVRKK 280 ALPDSGEDRD 290 TKEALKEFDF 300 LVTSEEGDNE 310 SRSAGDGTDW 320 EKEDQCLMPE 330 AWNVDQGVIT 340 KLKEQYKKER 350 KGKKGVKRPN 360 RSKLQDMLAN 370 LRDVDELPSL 380 QPSVGSPSRP 390 SSSRLPEHEI 400 NRADEVEALT 410 FPPSSGKSFI 420 MGADEALESE 430 LGLGELAGLT 440 VANEADSLTY 450 DIANNKDALR 460 KTWNPKFTLR 470 SHFDGIRALA 480 FHPIEPVLIT 490 ASEDHTLKMW 500 NLQKTAPAKK 510 STSLDVEPIY 520 TFRAHKGPVL 530 CVVMSSNGEQ 540 CYSGGTDGLI 550 QGWNTTNPNI 560 DPYDSYDPSV 570 LRGPLLGHTD 580 AVWGLAYSAA 590 HQRLLSCSAD 600 GTLRLWNTTE 610 VAPALSVFND 620 TKELGIPASV 630 DLVSSDPSHM 640 VASFSKGYTS 650 IFNMETQQRI 660 LTLESNVDTT 670 ANSSCQINRV 680 ISHPTLPISI 690 TAHEDRHIKF 700 YDNNTGKLIH 710 SMVAHLEAVT 720 SLAVDPNGLY 730 LMSGSHDCSI 740 RLWNLESKTC 750 IQEFTAHRKK 760 FEESIHDVAF 770 HPSKCYIASA 780 GADALAKVFV

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005923 bicellular tight junction
Cellular Component GO:0005829 cytosol
Cellular Component GO:0030425 dendrite
Cellular Component GO:0043197 dendritic spine
Cellular Component GO:0090443 FAR/SIN/STRIPAK complex
Cellular Component GO:0016020 membrane
Cellular Component GO:0043025 neuronal cell body
Cellular Component GO:0098794 postsynapse
Cellular Component GO:0014069 postsynaptic density
Cellular Component GO:0045211 postsynaptic membrane
Molecular Function GO:0070016 armadillo repeat domain binding
Molecular Function GO:0005516 calmodulin binding
Molecular Function GO:0030331 nuclear estrogen receptor binding
Molecular Function GO:0051721 protein phosphatase 2A binding
Molecular Function GO:0044877 protein-containing complex binding
Molecular Function GO:0030674 protein-macromolecule adaptor activity
Biological Process GO:0070830 bicellular tight junction assembly
Biological Process GO:0016358 dendrite development
Biological Process GO:0007626 locomotory behavior
Biological Process GO:0008285 negative regulation of cell population proliferation
Biological Process GO:0035330 regulation of hippo signaling
Biological Process GO:0009966 regulation of signal transduction
Biological Process GO:0016055 Wnt signaling pathway

Reference

[1] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.

[2] Guo X, Ren X, Yan C, Huang H. Quantitative Proteomics Reveals the Role of Lysine Lactylation in Lenalidomide-Resistance in Multiple Myeloma Cells.. ACS Chem Biol 20(7):1728-1738. 2025 Jul 18. PMID: 40590393.

[3] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[4] Chao L, Xu Y, Yang Y, Ao X, Liang J. Identification of lactylation-related biomarkers for diagnosis, prognosis, and treatment responsiveness in triple-negative breast cancer.. World J Surg Oncol 24(1):77. 2026 Jan 22. PMID: 41566505.

[5] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.