Search Results

Overview

Uniprot ID	O43818
Protein Name	U3 small nucleolar RNA-interacting protein 2
Gene Name	RRP9
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
113	DQVAGRLKEDVLEQR
125	EQRGRLQKLVAKEIQ
84	EKKLRLAKLYLEQLR

Function

Component of a nucleolar small nuclear ribonucleoprotein particle (snoRNP) thought to participate in the processing and modification of pre-ribosomal RNA (pre-rRNA) (PubMed:26867678). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797)

Protein Sequence

10 MSATAAARKR 20 GKPASGAGAG 30 AGAGKRRRKA 40 DSAGDRGKSK 50 GGGKMNEEIS 60 SDSESESLAP 70 RKPEEEEEEE 80 LEETAQEKKL 90 RLAKLYLEQL 100 RQQEEEKAEA 110 RAFEEDQVAG 120 RLKEDVLEQR 130 GRLQKLVAKE 140 IQAPASADIR 150 VLRGHQLSIT 160 CLVVTPDDSA 170 IFSAAKDCSI 180 IKWSVESGRK 190 LHVIPRAKKG 200 AEGKPPGHSS 210 HVLCMAISSD 220 GKYLASGDRS 230 KLILIWEAQS 240 CQHLYTFTGH 250 RDAVSGLAFR 260 RGTHQLYSTS 270 HDRSVKVWNV 280 AENSYVETLF 290 GHQDAVAALD 300 ALSRECCVTA 310 GGRDGTVRVW 320 KIPEESQLVF 330 YGHQGSIDCI 340 HLINEEHMVS 350 GADDGSVALW 360 GLSKKRPLAL 370 QREAHGLRGE 380 PGLEQPFWIS 390 SVAALLNTDL 400 VATGSHSSCV 410 RLWQCGEGFR 420 QLDLLCDIPL 430 VGFINSLKFS 440 SSGDFLVAGV 450 GQEHRLGRWW 460 RIKEARNSVC 470 IIPLRRVPVP PAAGS

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0031428	box C/D methylation guide snoRNP complex
Cellular Component	GO:0032040	small-subunit processome
Molecular Function	GO:0003723	RNA binding
Molecular Function	GO:0030515	snoRNA binding
Molecular Function	GO:0034511	U3 snoRNA binding
Biological Process	GO:0030490	maturation of SSU-rRNA
Biological Process	GO:0042274	ribosomal small subunit biogenesis
Biological Process	GO:0006364	rRNA processing
Cellular Component	GO:0005730	nucleolus
Cellular Component	GO:0005654	nucleoplasm

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[3] Bao Q, Wan N, He Z, Cao J, Yuan W et al.. Subcellular Proteomic Mapping of Lysine Lactylation.. J Am Soc Mass Spectrom 35(12):3221-3232. 2024 Dec 4. PMID: 39569522.

[4] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[5] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.