Search Results
Overview
| Uniprot ID | O43826 |
|---|---|
| Protein Name | Glucose-6-phosphate exchanger SLC37A4 |
| Gene Name | SLC37A4 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 207 | DPMPSEGKKGSLKEE |
| 290 | LSDRAMAKAGLSNYG |
Function
Inorganic phosphate and glucose-6-phosphate antiporter of the endoplasmic reticulum (PubMed:10026167, PubMed:21949678). Transports cytoplasmic glucose-6-phosphate into the lumen of the endoplasmic reticulum and translocates inorganic phosphate into the opposite direction (PubMed:41136424, PubMed:41225049, PubMed:33964207). Responsible for glucose production through glycogenolysis and gluconeogenesis and plays a central role in homeostatic regulation of blood glucose levels (PubMed:10026167, PubMed:21949678, PubMed:33964207)
Protein Sequence
10
MAAQGYGYYR
20
TVIFSAMFGG
30
YSLYYFNRKT
40
FSFVMPSLVE
50
EIPLDKDDLG
60
FITSSQSAAY
70
AISKFVSGVL
80
SDQMSARWLF
90
SSGLLLVGLV
100
NIFFAWSSTV
110
PVFAALWFLN
120
GLAQGLGWPP
130
CGKVLRKWFE
140
PSQFGTWWAI
150
LSTSMNLAGG
160
LGPILATILA
170
QSYSWRSTLA
180
LSGALCVVVS
190
FLCLLLIHNE
200
PADVGLRNLD
210
PMPSEGKKGS
220
LKEESTLQEL
230
LLSPYLWVLS
240
TGYLVVFGVK
250
TCCTDWGQFF
260
LIQEKGQSAL
270
VGSSYMSALE
280
VGGLVGSIAA
290
GYLSDRAMAK
300
AGLSNYGNPR
310
HGLLLFMMAG
320
MTVSMYLFRV
330
TVTSDSPKLW
340
ILVLGAVFGF
350
SSYGPIALFG
360
VIANESAPPN
370
LCGTSHAIVG
380
LMANVGGFLA
390
GLPFSTIAKH
400
YSWSTAFWVA
410
EVICAASTAA
420
FFLLRNIRTK
MGRVSKKAE
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005783 | endoplasmic reticulum |
| Cellular Component | GO:0005789 | endoplasmic reticulum membrane |
| Cellular Component | GO:0016020 | membrane |
| Molecular Function | GO:0061513 | glucose 6-phosphate:phosphate antiporter activity |
| Molecular Function | GO:0015152 | glucose-6-phosphate transmembrane transporter activity |
| Biological Process | GO:0006094 | gluconeogenesis |
| Biological Process | GO:0042593 | glucose homeostasis |
| Biological Process | GO:0006006 | glucose metabolic process |
| Biological Process | GO:0015760 | glucose-6-phosphate transport |
| Biological Process | GO:0035435 | phosphate ion transmembrane transport |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.