Search Results

Overview

Uniprot IDO43837
Protein NameIsocitrate dehydrogenase [NAD] subunit beta, mitochondrial
Gene NameIDH3B
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
105 EQVLSSMKENKVAII
114 NKVAIIGKIHTPMEY
122 IHTPMEYKGELASYD
135 YDMRLRRKLDLFANV
187 RGVIECLKIVTRAKS
199 AKSQRIAKFAFDYAT
350 SMIADAVKKVIKVGK
383 VIGHLQTKGS*****

Function

Plays a structural role to facilitate the assembly and ensure the full activity of the enzyme catalyzing the decarboxylation of isocitrate (ICT) into alpha-ketoglutarate. The heterodimer composed of the alpha (IDH3A) and beta (IDH3B) subunits and the heterodimer composed of the alpha (IDH3A) and gamma (IDH3G) subunits, have considerable basal activity but the full activity of the heterotetramer (containing two subunits of IDH3A, one of IDH3B and one of IDH3G) requires the assembly and cooperative function of both heterodimers

Protein Sequence

10 MAALSGVRWL 20 TRALVSAGNP 30 GAWRGLSTSA 40 AAHAASRSQA 50 EDVRVEGSFP 60 VTMLPGDGVG 70 PELMHAVKEV 80 FKAAAVPVEF 90 QEHHLSEVQN 100 MASEEKLEQV 110 LSSMKENKVA 120 IIGKIHTPME 130 YKGELASYDM 140 RLRRKLDLFA 150 NVVHVKSLPG 160 YMTRHNNLDL 170 VIIREQTEGE 180 YSSLEHESAR 190 GVIECLKIVT 200 RAKSQRIAKF 210 AFDYATKKGR 220 GKVTAVHKAN 230 IMKLGDGLFL 240 QCCEEVAELY 250 PKIKFETMII 260 DNCCMQLVQN 270 PYQFDVLVMP 280 NLYGNIIDNL 290 AAGLVGGAGV 300 VPGESYSAEY 310 AVFETGARHP 320 FAQAVGRNIA 330 NPTAMLLSAS 340 NMLRHLNLEY 350 HSSMIADAVK 360 KVIKVGKVRT 370 RDMGGYSTTT 380 DFIKSVIGHL QTKGS

Gene Ontology

Classification GO ID Description
Cellular Component GO:0045242 isocitrate dehydrogenase complex (NAD+)
Cellular Component GO:0005759 mitochondrial matrix
Cellular Component GO:0005739 mitochondrion
Cellular Component GO:0005634 nucleus
Molecular Function GO:0009055 electron transfer activity
Molecular Function GO:0004449 isocitrate dehydrogenase (NAD+) activity
Molecular Function GO:0000287 magnesium ion binding
Molecular Function GO:0051287 NAD binding
Biological Process GO:0006102 isocitrate metabolic process
Biological Process GO:0006099 tricarboxylic acid cycle

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.