Search Results
Overview
| Uniprot ID | O43847 |
|---|---|
| Protein Name | Nardilysin |
| Gene Name | NRDC |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 1025 | VTALIKLKECEDTHL |
Function
Cleaves peptide substrates on the N-terminus of arginine residues in dibasic pairs. Is a critical activator of BACE1- and ADAM17-mediated pro-neuregulin ectodomain shedding, involved in the positive regulation of axonal maturation and myelination. Required for proper functioning of 2-oxoglutarate dehydrogenase (OGDH) (By similarity)
Protein Sequence
10
MLRRVTVAAV
20
CATRRKLCEA
30
GRELAALWGI
40
ETRGRCEDSA
50
AARPFPILAM
60
PGRNKAKSTC
70
SCPDLQPNGQ
80
DLGENSRVAR
90
LGADESEEEG
100
RRGSLSNAGD
110
PEIVKSPSDP
120
KQYRYIKLQN
130
GLQALLISDL
140
SNMEGKTGNT
150
TDDEEEEEVE
160
EEEEDDDEDS
170
GAEIEDDDEE
180
GFDDEDEFDD
190
EHDDDLDTED
200
NELEELEERA
210
EARKKTTEKQ
220
SAAALCVGVG
230
SFADPDDLPG
240
LAHFLEHMVF
250
MGSLKYPDEN
260
GFDAFLKKHG
270
GSDNASTDCE
280
RTVFQFDVQR
290
KYFKEALDRW
300
AQFFIHPLMI
310
RDAIDREVEA
320
VDSEYQLARP
330
SDANRKEMLF
340
GSLARPGHPM
350
GKFFWGNAET
360
LKHEPRKNNI
370
DTHARLREFW
380
MRYYSSHYMT
390
LVVQSKETLD
400
TLEKWVTEIF
410
SQIPNNGLPR
420
PNFGHLTDPF
430
DTPAFNKLYR
440
VVPIRKIHAL
450
TITWALPPQQ
460
QHYRVKPLHY
470
ISWLVGHEGK
480
GSILSFLRKK
490
CWALALFGGN
500
GETGFEQNST
510
YSVFSISITL
520
TDEGYEHFYE
530
VAYTVFQYLK
540
MLQKLGPEKR
550
IFEEIRKIED
560
NEFHYQEQTD
570
PVEYVENMCE
580
NMQLYPLQDI
590
LTGDQLLFEY
600
KPEVIGEALN
610
QLVPQKANLV
620
LLSGANEGKC
630
DLKEKWFGTQ
640
YSIEDIENSW
650
AELWNSNFEL
660
NPDLHLPAEN
670
KYIATDFTLK
680
AFDCPETEYP
690
VKIVNTPQGC
700
LWYKKDNKFK
710
IPKAYIRFHL
720
ISPLIQKSAA
730
NVVLFDIFVN
740
ILTHNLAEPA
750
YEADVAQLEY
760
KLVAGEHGLI
770
IRVKGFNHKL
780
PLLFQLIIDY
790
LAEFNSTPAV
800
FTMITEQLKK
810
TYFNILIKPE
820
TLAKDVRLLI
830
LEYARWSMID
840
KYQALMDGLS
850
LESLLSFVKE
860
FKSQLFVEGL
870
VQGNVTSTES
880
MDFLKYVVDK
890
LNFKPLEQEM
900
PVQFQVVELP
910
SGHHLCKVKA
920
LNKGDANSEV
930
TVYYQSGTRS
940
LREYTLMELL
950
VMHMEEPCFD
960
FLRTKQTLGY
970
HVYPTCRNTS
980
GILGFSVTVG
990
TQATKYNSEV
1000
VDKKIEEFLS
1010
SFEEKIENLT
1020
EEAFNTQVTA
1030
LIKLKECEDT
1040
HLGEEVDRNW
1050
NEVVTQQYLF
1060
DRLAHEIEAL
1070
KSFSKSDLVN
1080
WFKAHRGPGS
1090
KMLSVHVVGY
1100
GKYELEEDGT
1110
PSSEDSNSSC
1120
EVMQLTYLPT
1130
SPLLADCIIP
1140
ITDIRAFTTT
1150
LNLLPYHKIV
K
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0009986 | cell surface |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0030425 | dendrite |
| Cellular Component | GO:0005759 | mitochondrial matrix |
| Molecular Function | GO:0061133 | endopeptidase activator activity |
| Molecular Function | GO:0048408 | epidermal growth factor binding |
| Molecular Function | GO:0046872 | metal ion binding |
| Molecular Function | GO:0004222 | metalloendopeptidase activity |
| Biological Process | GO:0120163 | negative regulation of cold-induced thermogenesis |
| Biological Process | GO:0050772 | positive regulation of axonogenesis |
| Biological Process | GO:0051044 | positive regulation of membrane protein ectodomain proteolysis |
| Biological Process | GO:0031643 | positive regulation of myelination |
| Biological Process | GO:0032760 | positive regulation of tumor necrosis factor production |
| Biological Process | GO:1903265 | positive regulation of tumor necrosis factor-mediated signaling pathway |
| Biological Process | GO:0006508 | proteolysis |
Reference
[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.