Search Results
Overview
| Uniprot ID | O43852 |
|---|---|
| Protein Name | Calumenin |
| Gene Name | CALU |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 281 | VYESDQNKDGKLTKE |
| 70 | QLTPEESKERLGKIV |
Function
Involved in regulation of vitamin K-dependent carboxylation of multiple N-terminal glutamate residues. Seems to inhibit gamma-carboxylase GGCX. Binds 7 calcium ions with a low affinity (By similarity)
Protein Sequence
10
MDLRQFLMCL
20
SLCTAFALSK
30
PTEKKDRVHH
40
EPQLSDKVHN
50
DAQSFDYDHD
60
AFLGAEEAKT
70
FDQLTPEESK
80
ERLGKIVSKI
90
DGDKDGFVTV
100
DELKDWIKFA
110
QKRWIYEDVE
120
RQWKGHDLNE
130
DGLVSWEEYK
140
NATYGYVLDD
150
PDPDDGFNYK
160
QMMVRDERRF
170
KMADKDGDLI
180
ATKEEFTAFL
190
HPEEYDYMKD
200
IVVQETMEDI
210
DKNADGFIDL
220
EEYIGDMYSH
230
DGNTDEPEWV
240
KTEREQFVEF
250
RDKNRDGKMD
260
KEETKDWILP
270
SDYDHAEAEA
280
RHLVYESDQN
290
KDGKLTKEEI
300
VDKYDLFVGS
310
QATDFGEALV
RHDEF
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005783 | endoplasmic reticulum |
| Cellular Component | GO:0005788 | endoplasmic reticulum lumen |
| Cellular Component | GO:0005789 | endoplasmic reticulum membrane |
| Cellular Component | GO:0005576 | extracellular region |
| Cellular Component | GO:0005794 | Golgi apparatus |
| Cellular Component | GO:0042470 | melanosome |
| Cellular Component | GO:0016020 | membrane |
| Cellular Component | GO:0033018 | sarcoplasmic reticulum lumen |
| Molecular Function | GO:0005509 | calcium ion binding |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.