Search Results
Overview
| Uniprot ID | O43895 |
|---|---|
| Protein Name | Xaa-Pro aminopeptidase 2 |
| Gene Name | XPNPEP2 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 360 | TKAVKNSKEQALLKA |
| 366 | SKEQALLKASHVRDA |
Function
Membrane-bound metalloprotease which catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides, such as Arg-Pro-Pro. May play a role in the metabolism of the vasodilator bradykinin
Protein Sequence
10
MARAHWGCCP
20
WLVLLCACAW
30
GHTKPVDLGG
40
QDVRNCSTNP
50
PYLPVTVVNT
60
TMSLTALRQQ
70
MQTQNLSAYI
80
IPGTDAHMNE
90
YIGQHDERRA
100
WITGFTGSAG
110
TAVVTMKKAA
120
VWTDSRYWTQ
130
AERQMDCNWE
140
LHKEVGTTPI
150
VTWLLTEIPA
160
GGRVGFDPFL
170
LSIDTWESYD
180
LALQGSNRQL
190
VSITTNLVDL
200
VWGSERPPVP
210
NQPIYALQEA
220
FTGSTWQEKV
230
SGVRSQMQKH
240
QKVPTAVLLS
250
ALEETAWLFN
260
LRASDIPYNP
270
FFYSYTLLTD
280
SSIRLFANKS
290
RFSSETLSYL
300
NSSCTGPMCV
310
QIEDYSQVRD
320
SIQAYSLGDV
330
RIWIGTSYTM
340
YGIYEMIPKE
350
KLVTDTYSPV
360
MMTKAVKNSK
370
EQALLKASHV
380
RDAVAVIRYL
390
VWLEKNVPKG
400
TVDEFSGAEI
410
VDKFRGEEQF
420
SSGPSFETIS
430
ASGLNAALAH
440
YSPTKELNRK
450
LSSDEMYLLD
460
SGGQYWDGTT
470
DITRTVHWGT
480
PSAFQKEAYT
490
RVLIGNIDLS
500
RLIFPAATSG
510
RMVEAFARRA
520
LWDAGLNYGH
530
GTGHGIGNFL
540
CVHEWPVGFQ
550
SNNIAMAKGM
560
FTSIEPGYYK
570
DGEFGIRLED
580
VALVVEAKTK
590
YPGSYLTFEV
600
VSFVPYDRNL
610
IDVSLLSPEH
620
LQYLNRYYQT
630
IREKVGPELQ
640
RRQLLEEFEW
650
LQQHTEPLAA
660
RAPDTASWAS
670
VLVVSTLAIL
GWSV
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0070062 | extracellular exosome |
| Cellular Component | GO:0005576 | extracellular region |
| Cellular Component | GO:0016020 | membrane |
| Cellular Component | GO:0005886 | plasma membrane |
| Cellular Component | GO:0098552 | side of membrane |
| Molecular Function | GO:0004177 | aminopeptidase activity |
| Molecular Function | GO:0046872 | metal ion binding |
| Molecular Function | GO:0070006 | metalloaminopeptidase activity |
| Biological Process | GO:0006508 | proteolysis |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.