Search Results
Overview
| Uniprot ID | O43903 |
|---|---|
| Protein Name | Growth arrest-specific protein 2 |
| Gene Name | GAS2 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 191 | PSPSPSSKSSGKKST |
| 196 | SSKSSGKKSTGNLLD |
| 280 | QISRVDGKTSPIQSK |
Function
Required to maintain microtubule bundles in inner ear supporting cells, affording them with mechanical stiffness to transmit sound energy through the cochlea
Protein Sequence
10
MCTALSPKVR
20
SGPGLSDMHQ
30
YSQWLASRHE
40
ANLLPMKEDL
50
ALWLTNLLGK
60
EITAETFMEK
70
LDNGALLCQL
80
AETMQEKFKE
90
SMDANKPTKN
100
LPLKKIPCKT
110
SAPSGSFFAR
120
DNTANFLSWC
130
RDLGVDETCL
140
FESEGLVLHK
150
QPREVCLCLL
160
ELGRIAARYG
170
VEPPGLIKLE
180
KEIEQEETLS
190
APSPSPSPSS
200
KSSGKKSTGN
210
LLDDAVKRIS
220
EDPPCKCPNK
230
FCVERLSQGR
240
YRVGEKILFI
250
RMLHNKHVMV
260
RVGGGWETFA
270
GYLLKHDPCR
280
MLQISRVDGK
290
TSPIQSKSPT
300
LKDMNPDNYL
310
VVSASYKAKK
EIK
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005884 | actin filament |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0016020 | membrane |
| Cellular Component | GO:0001725 | stress fiber |
| Molecular Function | GO:0051015 | actin filament binding |
| Molecular Function | GO:0008017 | microtubule binding |
| Biological Process | GO:0051764 | actin crosslink formation |
| Biological Process | GO:0006915 | apoptotic process |
| Biological Process | GO:0051726 | regulation of cell cycle |
| Biological Process | GO:0008360 | regulation of cell shape |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.
[2] Guo X, Ren X, Yan C, Huang H. Quantitative Proteomics Reveals the Role of Lysine Lactylation in Lenalidomide-Resistance in Multiple Myeloma Cells.. ACS Chem Biol 20(7):1728-1738. 2025 Jul 18. PMID: 40590393.