Search Results

Overview

Uniprot ID	O43929
Protein Name	Origin recognition complex subunit 4
Gene Name	ORC4
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
7	*MSSRKSKSNSLIHT

Function

Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. Binds histone H3 and H4 trimethylation marks H3K9me3, H3K27me3 and H4K20me3

Protein Sequence

10 MSSRKSKSNS 20 LIHTECLSQV 30 QRILRERFCR 40 QSPHSNLFGV 50 QVQYKHLSEL 60 LKRTALHGES 70 NSVLIIGPRG 80 SGKTMLINHA 90 LKELMEIEEV 100 SENVLQVHLN 110 GLLQINDKIA 120 LKEITRQLNL 130 ENVVGDKVFG 140 SFAENLSFLL 150 EALKKGDRTS 160 SCPVIFILDE 170 FDLFAHHKNQ 180 TLLYNLFDIS 190 QSAQTPIAVI 200 GLTCRLDILE 210 LLEKRVKSRF 220 SHRQIHLMNS 230 FGFPQYVKIF 240 KEQLSLPAEF 250 PDKVFAEKWN 260 ENVQYLSEDR 270 SVQEVLQKHF 280 NISKNLRSLH 290 MLLMLALNRV 300 TASHPFMTAV 310 DLMEASQLCS 320 MDSKANIVHG 330 LSVLEICLII 340 AMKHLNDIYE 350 EEPFNFQMVY 360 NEFQKFVQRK 370 AHSVYNFEKP 380 VVMKAFEHLQ 390 QLELIKPMER 400 TSGNSQREYQ 410 LMKLLLDNTQ 420 IMNALQKYPN 430 CPTDVRQWAT SSLSWL

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0000781	chromosome, telomeric region
Cellular Component	GO:0005737	cytoplasm
Cellular Component	GO:0005664	nuclear origin of replication recognition complex
Cellular Component	GO:0005730	nucleolus
Cellular Component	GO:0005654	nucleoplasm
Cellular Component	GO:0005634	nucleus
Cellular Component	GO:0000808	origin recognition complex
Molecular Function	GO:0005524	ATP binding
Molecular Function	GO:0003688	DNA replication origin binding
Molecular Function	GO:0000166	nucleotide binding
Biological Process	GO:0006270	DNA replication initiation
Biological Process	GO:0040038	polar body extrusion after meiotic divisions
Biological Process	GO:0051258	protein polymerization

Reference

[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[2] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[3] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.