Search Results
Overview
| Uniprot ID | O46427 |
|---|---|
| Protein Name | Pro-cathepsin H |
| Gene Name | CTSH |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 220 | HCKFQPDKAIAFVKD |
| 274 | YSSTSCHKTPDKVNH |
Function
Important for the overall degradation of proteins in lysosomes
Protein Sequence
10
MWAVLSLLCA
20
GAWLLGPPAC
30
GASNLAVSSF
40
EKLHFKSWMV
50
QHQKKYSLEE
60
YHHRLQVFVS
70
NWRKINAHNA
80
GNHTFKLGLN
90
QFSDMSFDEI
100
RHKYLWSEPQ
110
NCSATKGNYL
120
RGTGPYPPSM
130
DWRKKGNFVS
140
PVKNQGSCGS
150
CWTFSTTGAL
160
ESAVAIATGK
170
MLSLAEQQLV
180
DCAQNFNNHG
190
CQGGLPSQAF
200
EYIRYNKGIM
210
GEDTYPYKGQ
220
DDHCKFQPDK
230
AIAFVKDVAN
240
ITMNDEEAMV
250
EAVALYNPVS
260
FAFEVTNDFL
270
MYRKGIYSST
280
SCHKTPDKVN
290
HAVLAVGYGE
300
ENGIPYWIVK
310
NSWGPQWGMN
320
GYFLIERGKN
330
MCGLAACASY
PIPLV
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0097208 | alveolar lamellar body |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005615 | extracellular space |
| Cellular Component | GO:0005764 | lysosome |
| Molecular Function | GO:0004177 | aminopeptidase activity |
| Molecular Function | GO:0008656 | cysteine-type endopeptidase activator activity involved in apoptotic process |
| Molecular Function | GO:0004197 | cysteine-type endopeptidase activity |
| Molecular Function | GO:0008234 | cysteine-type peptidase activity |
| Molecular Function | GO:0004175 | endopeptidase activity |
| Molecular Function | GO:0030108 | HLA-A specific activating MHC class I receptor activity |
| Molecular Function | GO:0004252 | serine-type endopeptidase activity |
| Molecular Function | GO:0070324 | thyroid hormone binding |
| Biological Process | GO:0010815 | bradykinin catabolic process |
| Biological Process | GO:0097067 | cellular response to thyroid hormone stimulus |
| Biological Process | GO:0060448 | dichotomous subdivision of terminal units involved in lung branching |
| Biological Process | GO:0070371 | ERK1 and ERK2 cascade |
| Biological Process | GO:0006955 | immune response |
| Biological Process | GO:0002764 | immune response-regulating signaling pathway |
| Biological Process | GO:1905146 | lysosomal protein catabolic process |
| Biological Process | GO:0033619 | membrane protein proteolysis |
| Biological Process | GO:0001656 | metanephros development |
| Biological Process | GO:0010813 | neuropeptide catabolic process |
| Biological Process | GO:2001235 | positive regulation of apoptotic signaling pathway |
| Biological Process | GO:0030335 | positive regulation of cell migration |
| Biological Process | GO:0010634 | positive regulation of epithelial cell migration |
| Biological Process | GO:0010628 | positive regulation of gene expression |
| Biological Process | GO:0031648 | protein destabilization |
| Biological Process | GO:0006508 | proteolysis |
| Biological Process | GO:0051603 | proteolysis involved in protein catabolic process |
| Biological Process | GO:0032526 | response to retinoic acid |
| Biological Process | GO:0043129 | surfactant homeostasis |
| Biological Process | GO:0001913 | T cell mediated cytotoxicity |
| Biological Process | GO:0031638 | zymogen activation |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.