Search Results
Overview
| Uniprot ID | O46560 |
|---|---|
| Protein Name | Pyridoxal kinase |
| Gene Name | PDXK |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 112 | VDIVRELKQQNPRLV |
| 268 | NLKVACEKTVSAMHH |
Function
Catalyzes the phosphorylation of the dietary vitamin B6 vitamers pyridoxal (PL), pyridoxine (PN) and pyridoxamine (PM) to form pyridoxal 5'-phosphate (PLP), pyridoxine 5'-phosphate (PNP) and pyridoxamine 5'-phosphate (PMP), respectively (Probable) (PubMed:9924807). PLP is the active form of vitamin B6, and acts as a cofactor for over 140 different enzymatic reactions (By similarity)
Protein Sequence
10
MQAGSWVVGG
20
GDSDSRVLSI
30
QSHVVRGYVG
40
NRAATFPLQV
50
LGFEVDAVNS
60
VQFSNHTGYA
70
HWKGQVLNSD
80
ELHALYEGLK
90
LNNVNQYDYV
100
LTGYTRDKSF
110
LAMVVDIVRE
120
LKQQNPRLVY
130
VCDPVMGDKW
140
DGEGSMYVPE
150
DLLPVYREKV
160
VPVADIITPN
170
QFEAELLTGR
180
RIHSEEEALA
190
VMDMLHAMGP
200
DTVVITSSDL
210
PSPRGKDYLI
220
ALGSQRTRSP
230
DGSVATQRIR
240
MEICKVDAVF
250
VGTGDLFAAM
260
LLAWTHKHPN
270
NLKVACEKTV
280
SAMHHVLRRT
290
IQCAKAKAGE
300
GLKPSPAQLE
310
LRMVQSKRDI
320
EDPEVVVQAT
VL
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005829 | cytosol |
| Molecular Function | GO:0005524 | ATP binding |
| Molecular Function | GO:0046872 | metal ion binding |
| Molecular Function | GO:0008478 | pyridoxal kinase activity |
| Biological Process | GO:0009443 | pyridoxal 5'-phosphate salvage |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.