Search Results
Overview
| Uniprot ID | O54701 |
|---|---|
| Protein Name | Sodium/potassium/calcium exchanger 2 |
| Gene Name | Slc24a2 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 302 | INRNKVVKVTVSEAQ |
| 369 | LGSYGKLKYYDTMTE |
| 383 | EEGRFREKASILHKI |
Function
Calcium, potassium:sodium antiporter that transports 1 Ca(2+) and 1 K(+) in exchange for 4 Na(+) (PubMed:9461611). Required for learming and memory by regulating neuronal Ca(2+), which is essential for the development of synaptic plasticity (By similarity)
Protein Sequence
10
MDLHQSATVR
20
LLQEWCSHES
30
PSGCRRHYNT
40
RKKLKLIRVI
50
GLVMGLVAVS
60
TVPFSISAFT
70
ETYSQNNRGE
80
ASDVTGPRAA
90
PGHRQRTLLD
100
LNDKIRDYTP
110
QPPASQEDRS
120
ENGTDHAQGD
130
YPKDVFSLEE
140
RRKGAIILHV
150
IGMIYMFIAL
160
AIVCDEFFVP
170
SLTVITEKLG
180
ISDDVAGATF
190
MAAGGSAPEL
200
FTSLIGVFIA
210
HSNVGIGTIV
220
GSAVFNILFV
230
IGMCALFSRE
240
ILNLTWWPLF
250
RDVSFYIVDL
260
IMLIIFFLDN
270
VIMWWESLLL
280
LTAYFAYVVF
290
MKFNVQVERW
300
VKQMINRNKV
310
VKVTVSEAQA
320
KASTAGDKEE
330
PTLPNKPRLQ
340
RGGSSASLHN
350
SLMRNSIFQL
360
MIHTLDPLAE
370
ELGSYGKLKY
380
YDTMTEEGRF
390
REKASILHKI
400
AKKKCQVDEN
410
ERQNGAANHV
420
DYAAEKIELP
430
NSTSTEVEMT
440
PSSEASEPVQ
450
NGNLSHSIEA
460
ADAPQATETA
470
EEDDDQPLSL
480
SWPSNTRKQI
490
TFLIVLPIVF
500
PLWITLPDVR
510
KPASKKFFPI
520
TFFGSITWIA
530
VFSYLMVWWA
540
HQVGETIGIS
550
EEIMGLTILA
560
AGTSIPDLIT
570
SVIVARKGLG
580
DMAVSSSVGS
590
NIFDITVGLP
600
LPWLLYTIIH
610
RFKPVTVSSN
620
GLFCAIVLLF
630
IMLIFVILSI
640
ALCKWRMNKI
650
LGFIMFGLYF
660
AFLVVSVLLE
670
DKVLECPVSI
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0016020 | membrane |
| Cellular Component | GO:0005886 | plasma membrane |
| Cellular Component | GO:0098794 | postsynapse |
| Cellular Component | GO:0098793 | presynapse |
| Molecular Function | GO:0005262 | calcium channel activity |
| Molecular Function | GO:0008273 | calcium, potassium:sodium antiporter activity |
| Molecular Function | GO:0015293 | symporter activity |
| Biological Process | GO:0070509 | calcium ion import |
| Biological Process | GO:0098703 | calcium ion import across plasma membrane |
| Biological Process | GO:0070588 | calcium ion transmembrane transport |
| Biological Process | GO:0006816 | calcium ion transport |
| Biological Process | GO:0071486 | cellular response to high light intensity |
| Biological Process | GO:0036368 | cone photoresponse recovery |
| Biological Process | GO:0006874 | intracellular calcium ion homeostasis |
| Biological Process | GO:0007612 | learning |
| Biological Process | GO:0060292 | long-term synaptic depression |
| Biological Process | GO:0060291 | long-term synaptic potentiation |
| Biological Process | GO:0007613 | memory |
| Biological Process | GO:0034220 | monoatomic ion transmembrane transport |
| Biological Process | GO:0007602 | phototransduction |
| Biological Process | GO:0071805 | potassium ion transmembrane transport |
| Biological Process | GO:0065003 | protein-containing complex assembly |
| Biological Process | GO:0035725 | sodium ion transmembrane transport |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.