Search Results

Overview

Uniprot IDO54724
Protein NameCaveolae-associated protein 1
Gene NameCavin1
OrganismMus musculus

Kla Sites from experimental identification

Position Flanking peptide
175 LSVSKSLKESEALPE
278 TLEKRMNKLGTRLVP

Function

Plays an important role in caveolae formation and organization. Essential for the formation of caveolae in all tissues (PubMed:18056712, PubMed:18191225, PubMed:18840361, PubMed:30188967). Core component of the CAVIN complex which is essential for recruitment of the complex to the caveolae in presence of calveolin-1 (CAV1) (PubMed:19546242). Essential for normal oligomerization of CAV1 (PubMed:23652019). Promotes ribosomal transcriptional activity in response to metabolic challenges in the adipocytes and plays an important role in the formation of the ribosomal transcriptional loop (PubMed:27528195). Dissociates transcription complexes paused by DNA-bound TTF1, thereby releasing both RNA polymerase I and pre-RNA from the template (PubMed:10589839, PubMed:11139612, PubMed:9582279). The caveolae biogenesis pathway is required for the secretion of proteins such as GASK1A (PubMed:30188967)

Protein Sequence

10 MEDVTLHIVE 20 RPYSGFPDAS 30 SEGPEPTQGE 40 ARATEEPSGT 50 GSDELIKSDQ 60 VNGVLVLSLL 70 DKIIGAVDQI 80 QLTQAQLEER 90 QAEMEGAVQS 100 IQGELSKLGK 110 AHATTSNTVS 120 KLLEKVRKVS 130 VNVKTVRGSL 140 ERQAGQIKKL 150 EVNEAELLRR 160 RNFKVMIYQD 170 EVKLPAKLSV 180 SKSLKESEAL 190 PEKEGDELGE 200 GERPEDDTAA 210 IELSSDEAVE 220 VEEVIEESRA 230 ERIKRSGLRR 240 VDDFKKAFSK 250 EKMEKTKVRT 260 RENLEKTRLK 270 TKENLEKTRH 280 TLEKRMNKLG 290 TRLVPVERRE 300 KLKTSRDKLR 310 KSFTPDHVVY 320 ARSKTAVYKV 330 PPFTFHVKKI 340 REGEVEVLKA 350 TEMVEVGPED 360 DEVGAERGEA 370 TDLLRGSSPD 380 VHTLLEITEE 390 SDAVLVDKSD SD

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005901 caveola
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005829 cytosol
Cellular Component GO:0005783 endoplasmic reticulum
Cellular Component GO:0045121 membrane raft
Cellular Component GO:0005739 mitochondrion
Cellular Component GO:0005634 nucleus
Cellular Component GO:0005886 plasma membrane
Cellular Component GO:0032991 protein-containing complex
Molecular Function GO:0042802 identical protein binding
Molecular Function GO:0042134 rRNA primary transcript binding
Biological Process GO:2000147 positive regulation of cell motility
Biological Process GO:0009306 protein secretion
Biological Process GO:0009303 rRNA transcription
Biological Process GO:0006363 termination of RNA polymerase I transcription
Biological Process GO:0006361 transcription initiation at RNA polymerase I promoter

Reference

[1] Chang J, Wu W, Qian P, Lu Z, He X et al.. Multi-omics study on the effect of moderate-intensity exercise on protein lactylation in mouse muscle tissue.. Front Cell Dev Biol 12:1472338. 2024. PMID: 39935788.

[2] Zhuo W, Zhang M, Tan J, Gao Y, Wang Y et al.. Lysine lactylation analysis of proteins in the heart of the Kawasaki disease mouse model.. Front Cell Dev Biol 13:1550220. 2025. PMID: 40114965.

[3] Wu D, Tang Y, Li X, Xiong S, Zhang Z et al.. Characterization of protein lactylation in healthy and ischemic mouse hearts.. Front Cardiovasc Med 12:1644886. 2025. PMID: 41089239.