Search Results

Overview

Uniprot ID	O54924
Protein Name	Exocyst complex component 8
Gene Name	Exoc8
Organism	Rattus norvegicus

Kla Sites from experimental identification

Position	Flanking peptide
693	EGVGKPAKQLQDLRN

Function

Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane

Protein Sequence

10 MSDSGASRLR 20 RQLESGGFEA 30 RLYVKQLSQQ 40 SDGDRDLQEH 50 RQRVQALAEE 60 TAQNLKRNVY 70 QNYRQFIETA 80 REISYLESEM 90 YQLSHLLTEQ 100 KSSLESIPLA 110 LLPAAAAGAS 120 TGEDTAGAGP 130 RERGAAQAGF 140 LPGPAGVPRE 150 GPGTGEEGKQ 160 RTLTTLLEKV 170 EGCRDLLETP 180 GQYLVYNGDL 190 VEYEADHMAQ 200 LQRVHGFLMN 210 DCLLVATWLP 220 QRRGMYRYNA 230 LYPLDRLAVV 240 NVKDNPPMKD 250 MFKLLMFPES 260 RIFQAENAKI 270 KREWLEVLEE 280 TKRALSDKRR 290 REQEEAAALR 300 APPPVTSKGS 310 NPFEDEAEEE 320 LATPEAEEEK 330 VDLSMEWIQE 340 LPEDLDVCIA 350 QRDFEGAVDL 360 LDKLNHYLED 370 KPSPPSVKEL 380 RAKVDERVRQ 390 LTEVLVFELS 400 PDRSLRGGPK 410 ATRRAVSQLI 420 RLGQCTKACE 430 LFLRNRAAAV 440 HTAIRQLRIE 450 GATLLYIHKL 460 CHVFFTSLLE 470 TAREFETDFA 480 GTDSGCYSAF 490 VVWARSAMGM 500 FVDAFSKQVF 510 DSKESLSTAA 520 ECVKVAKEHC 530 QQLGEIGLDL 540 TFIIHALLVK 550 DIQGALLSYK 560 EIIIEATKHR 570 NSEEMWRRMN 580 LMTPEALGKL 590 KEEMRSCGVS 600 NFEQYTGDDC 610 WVNLSYTVVA 620 FTKQTMGFLE 630 EALKLYFPEL 640 HMVLLESLVE 650 VILVAVQHVD 660 YSLRCEQDPE 670 KKTFIRQNAS 680 FLYDTVLPVV 690 ERRFEEGVGK 700 PAKQLQDLRN 710 ASRLLRVNPE STTSVV

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0031252	cell leading edge
Cellular Component	GO:0000145	exocyst
Cellular Component	GO:0030426	growth cone
Cellular Component	GO:0005770	late endosome
Cellular Component	GO:0048471	perinuclear region of cytoplasm
Molecular Function	GO:0035091	phosphatidylinositol binding
Molecular Function	GO:0031267	small GTPase binding
Biological Process	GO:0007032	endosome organization
Biological Process	GO:0006887	exocytosis
Biological Process	GO:0022617	extracellular matrix disassembly
Biological Process	GO:0006893	Golgi to plasma membrane transport
Biological Process	GO:0008104	intracellular protein localization
Biological Process	GO:0015031	protein transport

Reference

[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.