Search Results
Overview
| Uniprot ID | O54975 |
|---|---|
| Protein Name | Xaa-Pro aminopeptidase 1 |
| Gene Name | Xpnpep1 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 322 | ICIAKAVKNSAESAG |
Function
Metalloaminopeptidase that catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides, such as Arg-Pro-Pro (PubMed:10095056). Contributes to the degradation of bradykinin (By similarity)
Protein Sequence
10
MAPKVTSELL
20
RQLRQAMRNS
30
ECVAEPIQAY
40
IIPSGDAHQS
50
EYIAPCDCRR
60
AFVSGFDGSA
70
GTAIITEEHA
80
AMWTDGRYFL
90
QAAKQMDNNW
100
TLMKMGLKDT
110
PTQEDWLVSV
120
LPEGSRVGVD
130
PLIIPTDYWK
140
KMAKVLRSAG
150
HHLVPVKENL
160
VDKIWTDRPE
170
RPCKPLLTLG
180
LDYTGISWKE
190
KVADLRLKMA
200
ERSIVWFVVT
210
ALDEIAWLFN
220
LRGSDVEHNP
230
VFFSYAIIGL
240
ERIMLFIDGD
250
RIDAPGVKQH
260
LLLDLGLEAE
270
YKIQVLPYKS
280
ILSELKTLCA
290
DLSPREKVWV
300
SDKASYAVSE
310
AIPKDHRCCM
320
PYTPICIAKA
330
VKNSAESAGM
340
RRAHIKDAVA
350
LCELFNWLEQ
360
EVPKGGVTEI
370
SAADKAEEFR
380
RQQADFVDLS
390
FPTISSTGPN
400
GAIIHYAPIP
410
ETNRTLSLDE
420
VYLIDSGAQY
430
KDGTTDVTRT
440
MHFGTPTAYE
450
KECFTYVLKG
460
HIAVSAAVFP
470
TGTKGHLLDS
480
FARSALWDSG
490
LDYLHGTGHG
500
VGSFLNVHEG
510
PCGISYKTFS
520
DEPLEAGMIV
530
TDEPGYYEDG
540
AFGIRIENVV
550
LVVPAKTKYN
560
FNNRGSLTFE
570
PLTLVPIQTK
580
MIDVDALTDK
590
ECDWLNSYHQ
600
TCRDVIGKEL
610
QTQGRQEALE
620
WLLRETEPIS
RQH
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Molecular Function | GO:0004177 | aminopeptidase activity |
| Molecular Function | GO:0030145 | manganese ion binding |
| Molecular Function | GO:0070006 | metalloaminopeptidase activity |
| Molecular Function | GO:0042803 | protein homodimerization activity |
| Biological Process | GO:0010815 | bradykinin catabolic process |
| Biological Process | GO:0043069 | negative regulation of programmed cell death |
| Biological Process | GO:0006508 | proteolysis |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.