Search Results
Overview
| Uniprot ID | O55047 |
|---|---|
| Protein Name | Serine/threonine-protein kinase tousled-like 2 |
| Gene Name | Tlk2 |
| Organism | Mus musculus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 247 | KLLIEKSKQEKMACR |
Function
Serine/threonine-protein kinase involved in the process of chromatin assembly and probably also DNA replication, transcription, repair, and chromosome segregation (By similarity). Phosphorylates the chromatin assembly factors ASF1A and ASF1B (By similarity). Phosphorylation of ASF1A prevents its proteasome-mediated degradation, thereby enhancing chromatin assembly (By similarity). Negative regulator of amino acid starvation-induced autophagy (By similarity)
Protein Sequence
10
MMEELHSLDP
20
RRQELLEARF
30
TGVGVSKGPL
40
NSESSNQSLC
50
SVGSLSDKEV
60
ETPEKKQNDQ
70
RNRKRKAEPY
80
DTSQGKGTPR
90
GHKISDYFER
100
RAEQPLYGLD
110
GSAAKEASEE
120
QSALPTLMSV
130
MLAKPRLDTE
140
QLAPRGAGLC
150
FTFVSAQQNS
160
PSSTGSGNTE
170
HSCSSQKQIS
180
IQHRQTQSDL
190
TIEKISALEN
200
SKNSDLEKKE
210
GRIDDLLRAN
220
CDLRRQIDEQ
230
QKMLEKYKER
240
LNRCVTMSKK
250
LLIEKSKQEK
260
MACRDKSMQD
270
RLRLGHFTTV
280
RHGASFTEQW
290
TDGYAFQNLI
300
KQQERINSQR
310
EEIERQRKML
320
AKRKPPAMGQ
330
APPATNEQKQ
340
RKSKTNGAEN
350
ETLTLAEYHE
360
QEEIFKLRLG
370
HLKKEEAEIQ
380
AELERLERVR
390
NLHIRELKRI
400
HNEDNSQFKD
410
HPTLNDRYLL
420
LHLLGRGGFS
430
EVYKAFDLTE
440
QRYVAVKIHQ
450
LNKNWRDEKK
460
ENYHKHACRE
470
YRIHKELDHP
480
RIVKLYDYFS
490
LDTDSFCTVL
500
EYCEGNDLDF
510
YLKQHKLMSE
520
KEARSIIMQI
530
VNALKYLNEI
540
KPPIIHYDLK
550
PGNILLVNGT
560
ACGEIKITDF
570
GLSKIMDDDS
580
YNSVDGMELT
590
SQGAGTYWYL
600
PPECFVVGKE
610
PPKISNKVDV
620
WSVGVIFYQC
630
LYGRKPFGHN
640
QSQQDILQEN
650
TILKATEVQF
660
PPKPVVTPEA
670
KAFIRRCLAY
680
RKEDRIDVQQ
690
LACDPYLLPH
700
IRKSVSTSSP
710
AGAAIASTSG
ASNNSSSN
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005882 | intermediate filament |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0048471 | perinuclear region of cytoplasm |
| Molecular Function | GO:0005524 | ATP binding |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0106310 | protein serine kinase activity |
| Molecular Function | GO:0004674 | protein serine/threonine kinase activity |
| Molecular Function | GO:0044325 | transmembrane transporter binding |
| Biological Process | GO:0030154 | cell differentiation |
| Biological Process | GO:0071480 | cellular response to gamma radiation |
| Biological Process | GO:0006325 | chromatin organization |
| Biological Process | GO:0007059 | chromosome segregation |
| Biological Process | GO:0006974 | DNA damage response |
| Biological Process | GO:0035556 | intracellular signal transduction |
| Biological Process | GO:0032435 | negative regulation of proteasomal ubiquitin-dependent protein catabolic process |
| Biological Process | GO:0051647 | nucleus localization |
| Biological Process | GO:0018105 | peptidyl-serine phosphorylation |
| Biological Process | GO:0006468 | protein phosphorylation |
| Biological Process | GO:1902275 | regulation of chromatin organization |
| Biological Process | GO:0007283 | spermatogenesis |
Reference
[1] Chang J, Wu W, Qian P, Lu Z, He X et al.. Multi-omics study on the effect of moderate-intensity exercise on protein lactylation in mouse muscle tissue.. Front Cell Dev Biol 12:1472338. 2024. PMID: 39935788.