Search Results

Overview

Uniprot IDO55126
Protein NameProtein NipSnap homolog 2
Gene NameNipsnap2
OrganismMus musculus

Kla Sites from experimental identification

Position Flanking peptide
138 ALTEVMNKLKENQEF
140 TEVMNKLKENQEFVN
53 VRKVDPRKDAHSNLL
62 AHSNLLAKKETSSLY
63 HSNLLAKKETSSLYK
70 KETSSLYKLQFHNVK
94 ICQEVLPKIHEGKQY

Function

Protein involved in mitophagy by facilitating recruitment of the autophagy machinery required for clearance of damaged mitochondria (PubMed:30982665). Accumulates on the mitochondria surface in response to mitochondrial depolarization and acts as a 'eat me' signal by recruiting proteins involved in selective autophagy, such as autophagy receptors (CALCOCO2/NDP52, NBR1, SQSTM1/p62, TAX1BP1 and WDFY3/ALFY) and ATG8 family proteins (MAP1LC3A, MAP1LC3B, MAP1LC3C, GABARAP, GABARAPL1 and GABARAPL2) (By similarity). May act as a positive regulator of L-type calcium channels (PubMed:22627147)

Protein Sequence

10 MAARVLLARG 20 GLLRPAAQSA 30 FLPGLRTVTS 40 SSHRAREDSW 50 LKSLFVRKVD 60 PRKDAHSNLL 70 AKKETSSLYK 80 LQFHNVKPEC 90 LDAYNKICQE 100 VLPKIHEGKQ 110 YPCTLVGTWN 120 TWYGEQDQAV 130 HLWRYEGGYP 140 ALTEVMNKLK 150 ENQEFVNFRK 160 ARSDMLLSRK 170 NQLLLEFSFW 180 NEPVPRPGPN 190 IYELRSYQLR 200 PGTMIEWGNY 210 WARAIRFRQD 220 SNEAIGGFFS 230 QIGQLYMVDH 240 LWAYRDLQTR 250 EDIRNAAWHK 260 HGWEELVYYT 270 VPLIQEMESR 280 IMIPLKTSPL Q

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005759 mitochondrial matrix
Cellular Component GO:0005741 mitochondrial outer membrane
Cellular Component GO:0005739 mitochondrion
Molecular Function GO:0030674 protein-macromolecule adaptor activity
Biological Process GO:0007005 mitochondrion organization
Biological Process GO:0000423 mitophagy
Biological Process GO:1901843 positive regulation of high voltage-gated calcium channel activity

Reference

[1] Chang J, Wu W, Qian P, Lu Z, He X et al.. Multi-omics study on the effect of moderate-intensity exercise on protein lactylation in mouse muscle tissue.. Front Cell Dev Biol 12:1472338. 2024. PMID: 39935788.

[2] Zhuo W, Zhang M, Tan J, Gao Y, Wang Y et al.. Lysine lactylation analysis of proteins in the heart of the Kawasaki disease mouse model.. Front Cell Dev Biol 13:1550220. 2025. PMID: 40114965.

[3] Wu D, Tang Y, Li X, Xiong S, Zhang Z et al.. Characterization of protein lactylation in healthy and ischemic mouse hearts.. Front Cardiovasc Med 12:1644886. 2025. PMID: 41089239.