Overview
| Uniprot ID | O60216 |
|---|
| Protein Name | Double-strand-break repair protein rad21 homolog |
|---|
| Gene Name | RAD21 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 323 |
TKAKRKRKLIVDSVK |
Function
As a member of the cohesin complex, involved in sister chromatid cohesion from the time of DNA replication in S phase to their segregation in mitosis, a function that is essential for proper chromosome segregation, post-replicative DNA repair, and the prevention of inappropriate recombination between repetitive regions (PubMed:11509732). The cohesin complex may also play a role in spindle pole assembly during mitosis (PubMed:11590136). In interphase, cohesins may function in the control of gene expression by binding to numerous sites within the genome (By similarity). May control RUNX1 gene expression (Probable). Binds to and represses APOB gene promoter (PubMed:25575569). May play a role in embryonic gut development, possibly through the regulation of enteric neuron development (By similarity)
Protein Sequence
10
MFYAHFVLSK
20
RGPLAKIWLA
30
AHWDKKLTKA
40
HVFECNLESS
50
VESIISPKVK
60
MALRTSGHLL
70
LGVVRIYHRK
80
AKYLLADCNE
90
AFIKIKMAFR
100
PGVVDLPEEN
110
REAAYNAITL
120
PEEFHDFDQP
130
LPDLDDIDVA
140
QQFSLNQSRV
150
EEITMREEVG
160
NISILQENDF
170
GDFGMDDREI
180
MREGSAFEDD
190
DMLVSTTTSN
200
LLLESEQSTS
210
NLNEKINHLE
220
YEDQYKDDNF
230
GEGNDGGILD
240
DKLISNNDGG
250
IFDDPPALSE
260
AGVMLPEQPA
270
HDDMDEDDNV
280
SMGGPDSPDS
290
VDPVEPMPTM
300
TDQTTLVPNE
310
EEAFALEPID
320
ITVKETKAKR
330
KRKLIVDSVK
340
ELDSKTIRAQ
350
LSDYSDIVTT
360
LDLAPPTKKL
370
MMWKETGGVE
380
KLFSLPAQPL
390
WNNRLLKLFT
400
RCLTPLVPED
410
LRKRRKGGEA
420
DNLDEFLKEF
430
ENPEVPREDQ
440
QQQHQQRDVI
450
DEPIIEEPSR
460
LQESVMEASR
470
TNIDESAMPP
480
PPPQGVKRKA
490
GQIDPEPVMP
500
PQQVEQMEIP
510
PVELPPEEPP
520
NICQLIPELE
530
LLPEKEKEKE
540
KEKEDDEEEE
550
DEDASGGDQD
560
QEERRWNKRT
570
QQMLHGLQRA
580
LAKTGAESIS
590
LLELCRNTNR
600
KQAAAKFYSF
610
LVLKKQQAIE
620
LTQEEPYSDI
630
IATPGPRFHI
I
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0000785 |
chromatin |
| Cellular Component |
GO:0005694 |
chromosome |
| Cellular Component |
GO:0000775 |
chromosome, centromeric region |
| Cellular Component |
GO:0008278 |
cohesin complex |
| Cellular Component |
GO:0000794 |
condensed nuclear chromosome |
| Cellular Component |
GO:0005829 |
cytosol |
| Cellular Component |
GO:0030893 |
meiotic cohesin complex |
| Cellular Component |
GO:0016020 |
membrane |
| Cellular Component |
GO:0016363 |
nuclear matrix |
| Cellular Component |
GO:0005654 |
nucleoplasm |
| Cellular Component |
GO:0005634 |
nucleus |
| Cellular Component |
GO:0000922 |
spindle pole |
| Molecular Function |
GO:0003682 |
chromatin binding |
| Molecular Function |
GO:0000987 |
cis-regulatory region sequence-specific DNA binding |
| Molecular Function |
GO:0140297 |
DNA-binding transcription factor binding |
| Molecular Function |
GO:0106222 |
lncRNA binding |
| Biological Process |
GO:0006915 |
apoptotic process |
| Biological Process |
GO:0051301 |
cell division |
| Biological Process |
GO:0007059 |
chromosome segregation |
| Biological Process |
GO:0006310 |
DNA recombination |
| Biological Process |
GO:0006351 |
DNA-templated transcription |
| Biological Process |
GO:0006302 |
double-strand break repair |
| Biological Process |
GO:0034089 |
establishment of meiotic sister chromatid cohesion |
| Biological Process |
GO:0034087 |
establishment of mitotic sister chromatid cohesion |
| Biological Process |
GO:0010972 |
negative regulation of G2/M transition of mitotic cell cycle |
| Biological Process |
GO:0034351 |
negative regulation of glial cell apoptotic process |
| Biological Process |
GO:0032691 |
negative regulation of interleukin-1 beta production |
| Biological Process |
GO:0045841 |
negative regulation of mitotic metaphase/anaphase transition |
| Biological Process |
GO:0043524 |
negative regulation of neuron apoptotic process |
| Biological Process |
GO:0032720 |
negative regulation of tumor necrosis factor production |
| Biological Process |
GO:0032733 |
positive regulation of interleukin-10 production |
| Biological Process |
GO:0045876 |
positive regulation of sister chromatid cohesion |
| Biological Process |
GO:0071168 |
protein localization to chromatin |
| Biological Process |
GO:0007131 |
reciprocal meiotic recombination |
| Biological Process |
GO:0006357 |
regulation of transcription by RNA polymerase II |
| Biological Process |
GO:1990414 |
replication-born double-strand break repair via sister chromatid exchange |
| Biological Process |
GO:0001666 |
response to hypoxia |
| Biological Process |
GO:0007062 |
sister chromatid cohesion |
Reference
[1] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.