Search Results

Overview

Uniprot IDO60244
Protein NameMediator of RNA polymerase II transcription subunit 14
Gene NameMED14
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
615 TRTNAKRKLSDDPCP

Function

Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors

Protein Sequence

10 MAPVQLENHQ 20 LVPPGGGGGG 30 SGGPPSAPAP 40 PPPGAAVAAA 50 AAAAASPGYR 60 LSTLIEFLLH 70 RAYSELMVLT 80 DLLPRKSDVE 90 RKIEIVQFAS 100 RTRQLFVRLL 110 ALVKWANNAG 120 KVEKCAMISS 130 FLDQQAILFV 140 DTADRLASLA 150 RDALVHARLP 160 SFAIPYAIDV 170 LTTGSYPRLP 180 TCIRDKIIPP 190 DPITKIEKQA 200 TLHQLNQILR 210 HRLVTTDLPP 220 QLANLTVANG 230 RVKFRVEGEF 240 EATLTVMGDD 250 PDVPWRLLKL 260 EILVEDKETG 270 DGRALVHSMQ 280 ISFIHQLVQS 290 RLFADEKPLQ 300 DMYNCLHSFC 310 LSLQLEVLHS 320 QTLMLIRERW 330 GDLVQVERYH 340 AGKCLSLSVW 350 NQQVLGRKTG 360 TASVHKVTIK 370 IDENDVSKPL 380 QIFHDPPLPA 390 SDSKLVERAM 400 KIDHLSIEKL 410 LIDSVHARAH 420 QKLQELKAIL 430 RGFNANENSS 440 IETALPALVV 450 PILEPCGNSE 460 CLHIFVDLHS 470 GMFQLMLYGL 480 DQATLDDMEK 490 SVNDDMKRII 500 PWIQQLKFWL 510 GQQRCKQSIK 520 HLPTISSETL 530 QLSNYSTHPI 540 GNLSKNKLFI 550 KLTRLPQYYI 560 VVEMLEVPNK 570 PTQLSYKYYF 580 MSVNAADRED 590 SPAMALLLQQ 600 FKENIQDLVF 610 RTKTGKQTRT 620 NAKRKLSDDP 630 CPVESKKTKR 640 AGEMCAFNKV 650 LAHFVAMCDT 660 NMPFVGLRLE 670 LSNLEIPHQG 680 VQVEGDGFSH 690 AIRLLKIPPC 700 KGITEETQKA 710 LDRSLLDCTF 720 RLQGRNNRTW 730 VAELVFANCP 740 LNGTSTREQG 750 PSRHVYLTYE 760 NLLSEPVGGR 770 KVVEMFLNDW 780 NSIARLYECV 790 LEFARSLPDI 800 PAHLNIFSEV 810 RVYNYRKLIL 820 CYGTTKGSSI 830 SIQWNSIHQK 840 FHISLGTVGP 850 NSGCSNCHNT 860 ILHQLQEMFN 870 KTPNVVQLLQ 880 VLFDTQAPLN 890 AINKLPTVPM 900 LGLTQRTNTA 910 YQCFSILPQS 920 STHIRLAFRN 930 MYCIDIYCRS 940 RGVVAIRDGA 950 YSLFDNSKLV 960 EGFYPAPGLK 970 TFLNMFVDSN 980 QDARRRSVNE 990 DDNPPSPIGG 1000 DMMDSLISQL 1010 QPPPQQQPFP 1020 KQPGTSGAYP 1030 LTSPPTSYHS 1040 TVNQSPSMMH 1050 TQSPGNLHAA 1060 SSPSGALRAP 1070 SPASFVPTPP 1080 PSSHGISIGP 1090 GASFASPHGT 1100 LDPSSPYTMV 1110 SPSGRAGNWP 1120 GSPQVSGPSP 1130 AARMPGMSPA 1140 NPSLHSPVPD 1150 ASHSPRAGTS 1160 SQTMPTNMPP 1170 PRKLPQRSWA 1180 ASIPTILTHS 1190 ALNILLLPSP 1200 TPGLVPGLAG 1210 SYLCSPLERF 1220 LGSVIMRRHL 1230 QRIIQQETLQ 1240 LINSNEPGVI 1250 MFKTDALKCR 1260 VALSPKTNQT 1270 LQLKVTPENA 1280 GQWKPDELQV 1290 LEKFFETRVA 1300 GPPFKANTLI 1310 AFTKLLGAPT 1320 HILRDCVHIM 1330 KLELFPDQAT 1340 QLKWNVQFCL 1350 TIPPSAPPIA 1360 PPGTPAVVLK 1370 SKMLFFLQLT 1380 QKTSVPPQEP 1390 VSIIVPIIYD 1400 MASGTTQQAD 1410 IPRQQNSSVA 1420 APMMVSNILK 1430 RFAEMNPPRQ 1440 GECTIFAAVR 1450 DLMANLTLPP GGRP

Gene Ontology

Classification GO ID Description
Cellular Component GO:0070847 core mediator complex
Cellular Component GO:0016592 mediator complex
Cellular Component GO:0016020 membrane
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Molecular Function GO:0042809 nuclear vitamin D receptor binding
Molecular Function GO:0003713 transcription coactivator activity
Molecular Function GO:0003712 transcription coregulator activity
Biological Process GO:0045893 positive regulation of DNA-templated transcription
Biological Process GO:0045944 positive regulation of transcription by RNA polymerase II
Biological Process GO:0032968 positive regulation of transcription elongation by RNA polymerase II
Biological Process GO:0060261 positive regulation of transcription initiation by RNA polymerase II
Biological Process GO:0006357 regulation of transcription by RNA polymerase II
Biological Process GO:0051123 RNA polymerase II preinitiation complex assembly

Reference

[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[2] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[3] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.