Search Results
Overview
| Uniprot ID | O60259 |
|---|---|
| Protein Name | Kallikrein-8 |
| Gene Name | KLK8 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 135 | DQASLGSKVKPISLA |
Function
Serine protease which is capable of degrading a number of proteins such as casein, fibrinogen, kininogen, fibronectin and collagen type IV. Also cleaves L1CAM in response to increased neural activity. Induces neurite outgrowth and fasciculation of cultured hippocampal neurons. Plays a role in the formation and maturation of orphan and small synaptic boutons in the Schaffer-collateral pathway, regulates Schaffer-collateral long-term potentiation in the hippocampus and is required for memory acquisition and synaptic plasticity. Involved in skin desquamation and keratinocyte proliferation. Plays a role in the secondary phase of pathogenesis following spinal cord injury
Protein Sequence
10
MGRPRPRAAK
20
TWMFLLLLGG
30
AWAGHSRAQE
40
DKVLGGHECQ
50
PHSQPWQAAL
60
FQGQQLLCGG
70
VLVGGNWVLT
80
AAHCKKPKYT
90
VRLGDHSLQN
100
KDGPEQEIPV
110
VQSIPHPCYN
120
SSDVEDHNHD
130
LMLLQLRDQA
140
SLGSKVKPIS
150
LADHCTQPGQ
160
KCTVSGWGTV
170
TSPRENFPDT
180
LNCAEVKIFP
190
QKKCEDAYPG
200
QITDGMVCAG
210
SSKGADTCQG
220
DSGGPLVCDG
230
ALQGITSWGS
240
DPCGRSDKPG
250
VYTNICRYLD
260
WIKKIIGSKG
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005576 | extracellular region |
| Cellular Component | GO:0005615 | extracellular space |
| Cellular Component | GO:0030141 | secretory granule |
| Cellular Component | GO:0097180 | serine protease inhibitor complex |
| Molecular Function | GO:0004252 | serine-type endopeptidase activity |
| Biological Process | GO:0043616 | keratinocyte proliferation |
| Biological Process | GO:0007613 | memory |
| Biological Process | GO:0048812 | neuron projection morphogenesis |
| Biological Process | GO:0051604 | protein maturation |
| Biological Process | GO:0006508 | proteolysis |
| Biological Process | GO:0050807 | regulation of synapse organization |
| Biological Process | GO:0009611 | response to wounding |
Reference
PMID: N/A