Search Results
Overview
| Uniprot ID | O60262 |
|---|---|
| Protein Name | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 |
| Gene Name | GNG7 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 12 | NNIAQARKLVEQLRI |
| 30 | IERIKVSKAASDLMS |
| 60 | PASENPFKDKKPCII |
Function
Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. Plays a role in the regulation of adenylyl cyclase signaling in certain regions of the brain. Plays a role in the formation or stabilization of a G protein heterotrimer (G(olf) subunit alpha-beta-gamma-7) that is required for adenylyl cyclase activity in the striatum (By similarity)
Protein Sequence
10
MSATNNIAQA
20
RKLVEQLRIE
30
AGIERIKVSK
40
AASDLMSYCE
50
QHARNDPLLV
60
GVPASENPFK
DKKPCIIL
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0070062 | extracellular exosome |
| Cellular Component | GO:0005834 | heterotrimeric G-protein complex |
| Cellular Component | GO:0005886 | plasma membrane |
| Cellular Component | GO:0045202 | synapse |
| Molecular Function | GO:0031681 | G-protein beta-subunit binding |
| Biological Process | GO:0007186 | G protein-coupled receptor signaling pathway |
| Biological Process | GO:0008277 | regulation of G protein-coupled receptor signaling pathway |
Reference
[1] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.